hydrogenchloride in 1,4-dioxane T=35°C; 5 h; Large scale;
参考文献
Briner, Paul H.; Fyfe, Matthew C. T.; Martin, Pierre; Murray, P. John; Naud, Frederic; Procter, Martin J.
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 346 - 348
Briner, Paul H.; Fyfe, Matthew C. T.; Martin, Pierre; Murray, P. John; Naud, Frederic; Procter, Martin J.
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 346 - 348
1: With potassium phosphate in 1,4-dioxane; methanol; toluene T=20°C; 2 h; 2: With Selectfluorreg; in 1,4-dioxane; methanol; toluene T=20°C; 0.5 h; 3: With hydrogenchloride in 1,4-dioxane; methanol; toluene Product distribution / selectivity;
参考文献
TAKEDA SAN DIEGO, INC.; MATTSON, Matthew
Patent: WO2011/115758 A1, 2011 ;
Location in patent: Page/Page column 13-14 ;
Briner, Paul H.; Fyfe, Matthew C. T.; Martin, Pierre; Murray, P. John; Naud, Frederic; Procter, Martin J.
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 346 - 348
