N-(5-溴-1,3-噻唑-2-基)-2,2,2-三氟乙酰胺合成路线 （共 3 条）
反应条件
triethylamine in dichloromethane
T=0 - 20°C; 3.25 h;
参考文献
OSI PHARMACEUTICALS, INC.
Patent: WO2004/72031 A2, 2004 ;
Location in patent: Page 45-46 ;
WO 2004/072031 A2
反应条件
in dichloromethane
T=0 - 20°C; 3.25 h;
参考文献
OSI PHARMACEUTICALS, INC.
Patent: WO2004/72066 A1, 2004 ;
Location in patent: Page 33-34 ;
WO 2004/072066 A1
反应条件
1: With n-butyllithium in tetrahydrofuran
T=-78°C;
2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in tetrahydrofuran
参考文献
Briner, Paul H.; Fyfe, Matthew C. T.; Martin, Pierre; Murray, P. John; Naud, Frederic; Procter, Martin J.
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 346 - 348
