2-((叔丁氧基羰基)氨基)噻唑-5-羧酸甲酯合成路线 （共 4 条）
反应条件
1: With water; sodium hydroxide in tetrahydrofuran; methanol T=60°C; 16 h; 2: With hydrogenchloride in tetrahydrofuran; methanol; water pH=1 - 2;
参考文献
TAKEDA SAN DIEGO, INC.; MATTSON, Matthew
Patent: WO2011/115758 A1, 2011 ;
Location in patent: Page/Page column 8 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 1 h; 2: With sodium hydroxide; water in tetrahydrofuran 0.5 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; MENG, Wei; CHENG, Peter T. W.
Patent: WO2011/130459 A1, 2011 ;
Location in patent: Page/Page column 64; 65 ;
WO 2011/130459 A1
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in tetrahydrofuran
T=20°C; 16 h;
参考文献
TAKEDA SAN DIEGO, INC.; MATTSON, Matthew
Patent: WO2011/115758 A1, 2011 ;
Location in patent: Page/Page column 8 ;
反应条件
1.1: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 60 °C
1.2: pH 1 - 2
2.1: Selectfluorreg;; K3PO4 / water; 2-methyl tetrahydrofuran / 3 h / 2 - 20 °C
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参考文献
TAKEDA SAN DIEGO, INC.; MATTSON, Matthew
Patent: WO2011/115758 A1, 2011 ;
