2-羟基-N-(1,2,3,10-四甲氧基-9-氧代-6,7-二氢-5H-苯并[d]庚搭烯-7-基)乙酰胺合成路线 (共 5 条)
反应条件
1-hydroxy-pyrrolidine-2,5-dione; triethylamine; diisopropyl-carbodiimide in dichloromethane
16 h;
参考文献
Crielaard, Bart J.; Van Der Wal, Steffen; Le, Huong Thu; Bode, Alois T.L.; Lammers, Twan; Hennink, Wim E.; Schiffelers, Raymond M.; Fens, Marcel H.A.M.; Storm, Gert
European Journal of Pharmaceutical Sciences, 2012 , vol. 45, # 4 p. 429 - 435
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / acetonitrile / 3.5 h / 20 °C / Reflux
2: methanol; sodium methylate / 0.75 h / 4 °C
3: trifluoroacetic acid / dichloromethane / 2 h
4: 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; diisopropyl-carbodiimide / dichloromethane / 16 h
View Scheme
参考文献
Crielaard, Bart J.; Van Der Wal, Steffen; Le, Huong Thu; Bode, Alois T.L.; Lammers, Twan; Hennink, Wim E.; Schiffelers, Raymond M.; Fens, Marcel H.A.M.; Storm, Gert
European Journal of Pharmaceutical Sciences, 2012 , vol. 45, # 4 p. 429 - 435
反应条件
1: trifluoroacetic acid / dichloromethane / 2 h
2: 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; diisopropyl-carbodiimide / dichloromethane / 16 h
View Scheme
参考文献
Crielaard, Bart J.; Van Der Wal, Steffen; Le, Huong Thu; Bode, Alois T.L.; Lammers, Twan; Hennink, Wim E.; Schiffelers, Raymond M.; Fens, Marcel H.A.M.; Storm, Gert
European Journal of Pharmaceutical Sciences, 2012 , vol. 45, # 4 p. 429 - 435
反应条件
1: methanol; sodium methylate / 0.75 h / 4 °C
2: trifluoroacetic acid / dichloromethane / 2 h
3: 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; diisopropyl-carbodiimide / dichloromethane / 16 h
View Scheme
参考文献
Crielaard, Bart J.; Van Der Wal, Steffen; Le, Huong Thu; Bode, Alois T.L.; Lammers, Twan; Hennink, Wim E.; Schiffelers, Raymond M.; Fens, Marcel H.A.M.; Storm, Gert
European Journal of Pharmaceutical Sciences, 2012 , vol. 45, # 4 p. 429 - 435
反应条件
pyridine
2.) dichloromethane; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Iorio, Maria A.; Molinari, Marisa; Brossi, Arnold
Canadian Journal of Chemistry, 1981 , vol. 59, p. 283 - 284