4,5-二甲基噻唑-2-甲醛合成路线 （共 3 条）
反应条件
1: 4,5-dimethyl-thiazole With n-butyllithium in tetrahydrofuran; hexanes
T=-78°C; Inert atmosphere;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexanes
T=-78 - 60°C; 2.5 h;
参考文献
Mutabilis
Patent: EP2141164 A1, 2010 ;
Location in patent: Page/Page column 10-11 ;
反应条件
Diazotization.Reaktion ueber mehrere Stufen;
参考文献
Beyer et al.
Chemische Berichte, 1957 , vol. 90, p. 2372,2377
反应条件
methanol; sodium tetrahydroborate
T=40°C;
参考文献
GLAXOSMITHKLINE LLC; QIN, Donghui; CHRISTENSEN, Sieg; WU, Chengde; ZHANG, Zhiliu; YU, Haiyu; YUAN, Jiangxing
Patent: WO2013/149362 A1, 2013 ;
Location in patent: Page/Page column 49 ;
