1,5-二甲基-4-乙氧甲酰咪唑合成路线 （共 3 条）
反应条件
1: 4-methylimidazole-5-carboxylic acid ethyl ester With sodium hydride in tetrahydrofuran; mineral oil
T=20°C; Inert atmosphere;
2: methyl iodide in tetrahydrofuran; mineral oil
T=0 - 20°C; Inert atmosphere;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; DAHMANN, Georg; DOLLINGER, Horst; GNAMM, Christian; FIEGEN, Dennis; HOFFMANN, Matthias; LAMB, David, James; KLICIC, Jasna; SCHNAPP, Andreas
Patent: WO2013/156608 A1, 2013 ;
Location in patent: Page/Page column 48 ;
反应条件
sodium hydride
1.) THF, 2.) overnight; Yield given. Multistep reaction;
参考文献
Lam, Bing L.; Wellman, George R.; Labaw, Clifford S.
Journal of Organic Chemistry, 1982 , vol. 47, # 1 p. 144 - 147
反应条件
sodium hydroxide in water
18 h; Heating;
参考文献
Kim, Choong S.; Lee, Kee J.; Kim, Hong S.; Chae, Yung B.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1417 - 1418
