(R)-1-(2-溴苯基)丙烷-1-醇合成路线 （共 5 条）
反应条件
1: 87 percent / potassium hydrogen sulfate, phosphorus pentoxide, 4-tert-butylcatechol / 230 °C 2: 1.) Mg / 1.) THF, 60 deg C, 40 min; 2.) ether, -78 to 5 deg C, overnight View Scheme
参考文献
Journal of the American Chemical Society, , vol. 107, # 6 p. 1710 - 1717
反应条件
in N,N-dimethyl-formamide
12 h; Inert atmosphereReflux;
参考文献
COUNCIL OF SCIENTIFIC and INDUSTRIAL RESEARCH; REDDY, Santhosh, Rekula; PRAGATI, Kishore, Prasad; NAGA, Kiran, Chaithanya, Indukuru; SUDALAI, Arumugam
Patent: WO2013/102935 A2, 2013 ;
Location in patent: Page/Page column 20 ;
参考文献
Soai, Kenso; Hori, Hiroshi; Kawahara, Masato
Tetrahedron: Asymmetry, 1991 , vol. 2, # 4 p. 253 - 254
反应条件
1.1: 75 percent / chlorodimethylsilane / InCl3 / CH2Cl2 / 0.75 h / 20 °C
2.1: Mg / diethyl ether / 20 °C
2.2: 51 percent / tetrahydrofuran; diethyl ether / -78 °C
View Scheme
参考文献
Garcia Ruano, Jose L.; Aranda, M. Teresa; Puente, Margarita
Tetrahedron, 2005 , vol. 61, # 42 p. 10099 - 10104
反应条件
silica gel; pyridinium chlorochromate in dichloromethane
T=20°C; 2 h; Inert atmosphere;
参考文献
Mahendar, Lodi; Krishna, Jonnada; Gopi Krishna Reddy, Alavala; Venkat Ramulu, Bokka; Satyanarayana, Gedu
Organic Letters, 2012 , vol. 14, # 2 p. 628 - 631
