1: With triethylamine in water T=0 - 5°C; 2: With sodium 2-ethyl hexanoate in water; acetone T=0 - 5°C;

1: (6R,7R)-7-amino-[3-[[2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl]thio]-methyl]-8-oxo-5-thia-1-azabicyclo-[4.2.0]oct-2-ene-2-carboxylic acid With N,O-bis-(trimethylsilyl)-acetamide in dichloromethane T=20°C; 2 h; 2: diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate in dichloromethane T=20°C; 4 h; 3: With sodium hydroxide in dichloromethane; water T=15 - 20°C; pH=7.5 - 7.8;

1: With triethylamine in methanol T=-2 - 3°C; 2: With sodium 2-ethyl hexanoate in water; isopropyl alcohol T=26 - 30°C; 2 h; Product distribution / selectivity;