2-氯-N-(2-丙炔-1-基)乙酰胺合成路线 (共 4 条)
反应条件
copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran T=20°C; 20 h;
参考文献
Pfizer Inc
Patent: US2005/101618 A1, 2005 ;
Location in patent: Page/Page column 18 ;
US 20050101618 A1
反应条件
diisopropylamine; Pd(PPh3)2Cl2 in tetrahydrofuran; dichloromethane
参考文献
Pfizer Inc.
Patent: US6284764 B1, 2001 ;
反应条件
triethylamine in dichloromethane
T=20°C; 4 h;
参考文献
Rajagopal, Basker; Chen, Ying-Yu; Chen, Chun-Chi; Liu, Xuan-Yu; Wang, Huei-Ren; Lin, Po-Chiao
Journal of Organic Chemistry, 2014 , vol. 79, # 3 p. 1254 - 1264
反应条件
sodium hydrogencarbonate in dichloromethane
3 h;
参考文献
Milne, Mark; Chicas, Kirby; Li, Alex; Bartha, Robert; Hudson, Robert H. E.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 2 p. 287 - 292