(9CI)-1,2-二氢-6-甲基吡咯并[1,2-a]吡嗪-3(4H)-酮合成路线 （共 7 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 70°C; 1 h;
参考文献
Bhowmik, Subhendu; Kumar, Anil K.S.; Batra, Sanjay
Tetrahedron Letters, 2013 , vol. 54, # 18 p. 2251 - 2254
反应条件
hydrogenchloride; acetic acid in water
T=20°C; 24 h;
参考文献
Trushkov, Igor V.; Nevolina, Tatyana A.; Shcherbinin, Vitaly A.; Sorotskaya, Lyudmila N.; Butin, Alexander V.
Tetrahedron Letters, 2013 , vol. 54, # 30 p. 3974 - 3976
反应条件
hydrazine hydrate in ethanol; N,N-dimethyl-formamide
0.75 h; Heating;
参考文献
Stetter, Hermann; Lappe, Peter
Liebigs Annalen der Chemie, 1980 , # 5 p. 703 - 714
反应条件
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 1 h / -15 °C
2.1: hydrogenchloride; acetic acid / water / 12 h / 0 - 20 °C
2.2: 3 h / pH Ca. 7 / |Reflux
View Scheme
参考文献
Bhowmik, Subhendu; Kumar, Anil K.S.; Batra, Sanjay
Tetrahedron Letters, 2013 , vol. 54, # 18 p. 2251 - 2254
反应条件
1: 65 percent / NaOAc / ethanol / 16 h / Heating
2: 87 percent / H2N-NH2*H2O / ethanol; dimethylformamide / 0.75 h / Heating
View Scheme
参考文献
Stetter, Hermann; Lappe, Peter
Liebigs Annalen der Chemie, 1980 , # 5 p. 703 - 714
反应条件
1: hydrazine hydrate / ethanol / 0.08 h / |Reflux
2: hydrogenchloride; acetic acid / water / 24 h / 20 °C
View Scheme
参考文献
Trushkov, Igor V.; Nevolina, Tatyana A.; Shcherbinin, Vitaly A.; Sorotskaya, Lyudmila N.; Butin, Alexander V.
Tetrahedron Letters, 2013 , vol. 54, # 30 p. 3974 - 3976
反应条件
1: hydroxylamine hydrochloride; pyridine / ethanol
2: sodium hydroxide; zinc
3: benzene / 1 h / 20 °C
4: hydrazine hydrate / ethanol / 0.08 h / |Reflux
5: hydrogenchloride; acetic acid / water / 24 h / 20 °C
View Scheme
参考文献
Trushkov, Igor V.; Nevolina, Tatyana A.; Shcherbinin, Vitaly A.; Sorotskaya, Lyudmila N.; Butin, Alexander V.
Tetrahedron Letters, 2013 , vol. 54, # 30 p. 3974 - 3976
