2-氯-N-甲基乙酰苯胺合成路线 （共 10 条）
反应条件
hydrogenchloride in water; ethylene glycol 24 h; RefluxInert atmosphere;
参考文献
Zhu, Manghong; Zhang, Chen; Nwachukwu, Jerome C.; Srinivasan, Sathish; Cavett, Valerie; Zheng, Yangfan; Carlson, Kathryn E.; Dong, Chune; Katzenellenbogen, John A.; Nettles, Kendall W.; Zhou, Hai-Bing
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 43 p. 8692 - 8700
反应条件
lithium diisopropyl amide in tetrahydrofuran 0.5 h; Ambient temperatureIrradiation;
参考文献
Goehring, R. Richard; Sachdeva, Yesh P.; Pisipati, Jyothi S.; Sleevi, Mark C.; Wolfe, James F.
Journal of the American Chemical Society, 1985 , vol. 107, # 2 p. 435 - 443
反应条件
KNH2 in ammonia; benzene 0.5 h; Irradiation;
参考文献
Goehring, R. Richard; Sachdeva, Yesh P.; Pisipati, Jyothi S.; Sleevi, Mark C.; Wolfe, James F.
Journal of the American Chemical Society, 1985 , vol. 107, # 2 p. 435 - 443
反应条件
1: benzene / 1 h / Heating
View Scheme
参考文献
Goehring, R. Richard; Sachdeva, Yesh P.; Pisipati, Jyothi S.; Sleevi, Mark C.; Wolfe, James F.
Journal of the American Chemical Society, 1985 , vol. 107, # 2 p. 435 - 443
反应条件
1: N-(2-chlorophenyl)-acetamide With sodium hydride in tetrahydrofuran
T=0°C; 0.5 h; Inert atmosphere;
2: methyl iodide in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
Zhu, Manghong; Zhang, Chen; Nwachukwu, Jerome C.; Srinivasan, Sathish; Cavett, Valerie; Zheng, Yangfan; Carlson, Kathryn E.; Dong, Chune; Katzenellenbogen, John A.; Nettles, Kendall W.; Zhou, Hai-Bing
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 43 p. 8692 - 8700
参考文献
Goehring, R. Richard; Sachdeva, Yesh P.; Pisipati, Jyothi S.; Sleevi, Mark C.; Wolfe, James F.
Journal of the American Chemical Society, 1985 , vol. 107, # 2 p. 435 - 443
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate
1.) toluene, 30-35 deg C, 30 min, 2.) toluene, 30-35 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Kalkote; Choudhary; Natu; Lahoti; Ayyangar
Synthetic Communications, 1991 , vol. 21, # 18-19 p. 1889 - 1900
参考文献
Grammaticakis
Bulletin de la Societe Chimique de France, 1949 , p. 761,764
Bulletin de la Societe Chimique de France, 1968 , p. 1057,1059
参考文献
Huisgen et al.
Chemische Berichte, 1959 , vol. 92, p. 3223,3236
反应条件
KNH2 in ammonia; benzene
0.5 h; Irradiation;
参考文献
Goehring, R. Richard; Sachdeva, Yesh P.; Pisipati, Jyothi S.; Sleevi, Mark C.; Wolfe, James F.
Journal of the American Chemical Society, 1985 , vol. 107, # 2 p. 435 - 443
