(5-甲氧基-1H-吲哚-2-基)苯基甲酮合成路线 （共 12 条）
反应条件
aq. 10percent NaOH in ethanol 12 h; Heating;
参考文献
Mahboobi, Siavosh; Teller, Steffen; Pongratz, Herwig; Hufsky, Harald; Sellmer, Andreas; Botzki, Alexander; Uecker, Andrea; Beckers, Thomas; Baasner, Silke; Schaechtele, Christoph; Ueberall, Florian; Kassack, Matthias U.; Dove, Stefan; Boehmer, Frank-D.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 5 p. 1002 - 1018
反应条件
1: 2-(dimethyl-λ4-sulfanylidene)-1-phenyl-ethanone With caesium carbonate in anhydrous xylene T=20°C; 0.5 h; 2: C15H16ClNO3S in anhydrous xylene T=20°C;
参考文献
Yang, Qing-Qing; Xiao, Cong; Lu, Liang-Qiu; An, Jing; Tan, Fen; Li, Bin-Jie; Xiao, Wen-Jing
Angewandte Chemie - International Edition, 2012 , vol. 51, # 36 p. 9137 - 9140
反应条件
sodium hydroxide in N,N-dimethyl-formamide
参考文献
Gorgos, V. I.; Zorin, L. M.; Zhungietu, G. I.; Rekhter, M. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 11 p. 1179 - 1181
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , # 11 p. 1490 - 1492
反应条件
1.1: n-BuLi; diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C 1.2: 86 percent / tetrahydrofuran / -78 - 20 °C 2.1: 61 percent / pyridinium dichromate; pyridinium trifluoroacetate / CH2Cl2 / 20 °C 3.1: 90 percent / TBAF / tetrahydrofuran; methanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 5 p. 1002 - 1018
反应条件
1: 61 percent / pyridinium dichromate; pyridinium trifluoroacetate / CH2Cl2 / 20 °C 2: 90 percent / TBAF / tetrahydrofuran; methanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 5 p. 1002 - 1018
反应条件
1.1: NaH / dimethylformamide / 1 h / 20 °C 1.2: 82 percent / dimethylformamide / 1 h / 20 °C 2.1: n-BuLi; diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C 2.2: 86 percent / tetrahydrofuran / -78 - 20 °C 3.1: 61 percent / pyridinium dichromate; pyridinium trifluoroacetate / CH2Cl2 / 20 °C 4.1: 90 percent / TBAF / tetrahydrofuran; methanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 5 p. 1002 - 1018
反应条件
T=220 - 230°C; 0.2 h;
参考文献
Gorgos, V. I.; Zorin, L. M.; Zhungietu, G. I.; Rekhter, M. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 11 p. 1179 - 1181
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , # 11 p. 1490 - 1492
反应条件
1: tetrahydrofuran; diethyl ether / 0.83 h / 0 - 20 °C 2: MnO2 / CHCl3 / 0.67 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 16 p. 4896 - 4911
反应条件
1.1: LDA / tetrahydrofuran / 0.5 h / 0 °C 1.2: 86 percent / tetrahydrofuran / -78 - 20 °C 2.1: 61 percent / pyridinium dichromate; pyridinium trifluoroacetate / CH2Cl2 3.1: 90 percent / aq. 10percent NaOH / ethanol / 12 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 26 p. 4535 - 4553
反应条件
1: NaOH / methanol 2: dimethylformamide 3: 20percent aq. NaOH / 12 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 4 p. 200
