1,1,2-乙烷三甲酸三乙酯合成路线 （共 41 条）
反应条件
1: NaBH4 / 2-methyl-propan-2-ol; methanol 2: p-toluenesulfonic acid / tetrahydrofuran 3: CBr4; PPh3 / tetrahydrofuran / 0 °C View Scheme
参考文献
Wang, Ji-Quan; Zheng, Qi-Huang; Fei, Xiangshu; Mock, Bruce H.; Hutchins, Gary D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3933 - 3938
反应条件
1: sodium tetrahydroborate / methanol; tert-butyl alcohol / 0.5 h / Reflux 2: toluene-4-sulfonic acid / tetrahydrofuran / 4 h / 20 °C 3: pyridine / dichloromethane / 5 h / 20 °C View Scheme
参考文献
You, Hyun; Youn, Hyung-Seop; Im, Isak; Bae, Man-Ho; Lee, Sang-Kook; Ko, Hyojin; Eom, Soo Hyun; Kim, Yong-Chul
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1153 - 1164
反应条件
p-toluenesulfonic acid monohydrate in tetrahydrofuran; acetone
参考文献
BEECHAM GROUP PLC
Patent: EP141927 B1, 1991 ;
反应条件
1: NaBH4 / 2-methyl-propan-2-ol; methanol 2: p-toluenesulfonic acid / tetrahydrofuran View Scheme
参考文献
Wang, Ji-Quan; Zheng, Qi-Huang; Fei, Xiangshu; Mock, Bruce H.; Hutchins, Gary D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3933 - 3938
反应条件
1: 100 percent / sodium borohydride, MeOH / 2-methyl-propan-2-ol / 0.5 h / Heating 2: 41 percent / p-TsOH*H2O / tetrahydrofuran / 0.5 h / Ambient temperature 3: 87 percent / CBr4, PPh3 / dimethylformamide / 0.5 h / 0 °C 4: 64 percent / K2CO3 / dimethylformamide / 5 h / Ambient temperature 5: cyclohexene / 10percent Pd/C / ethanol / Heating 6: aq. HCl / ethanol; cyclohexene; methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 9 p. 1636 - 1642
反应条件
1: triethyl ethane-1,1,2-tricarboxylate With sodium methylate in methanol T=20°C; 3 h; 2: methanimidamide monoacetate in methanol T=20 - 68°C; 3: With hydrogenchloride in methanol T=10 - 15°C; pH=1.5 - 2;
参考文献
US2010/120801 A1, ;
Page/Page column 61 ;
反应条件
1: (i) LiAlH4, (ii) /BRN= 385737/
2: 515 °C
View Scheme
参考文献
Bailey,W.J. et al.
Journal of Organic Chemistry, 1962 , vol. 27, p. 1975 - 1978
反应条件
1: triethyl ethane-1,1,2-tricarboxylate With sodium in ethanol
Heating;
2: allyl bromide in ethanol
T=82°C; 1 h;
参考文献
Brace, Neal O.
Journal of Fluorine Chemistry, 2003 , vol. 123, # 2 p. 237 - 248
参考文献
Hjelt
Chemische Berichte, 1883 , vol. 16, p. 335
反应条件
1.1: Na / ethanol / Heating
1.2: 49.1 g / ethanol / 1 h / 82 °C
2.1: 44.3 g / benzoyl peroxide / 3.5 h / 99 °C
View Scheme
参考文献
Brace, Neal O.
Journal of Fluorine Chemistry, 2003 , vol. 123, # 2 p. 237 - 248
