5-氯-4-甲酰基噻吩-2-羧酸乙酯合成路线 （共 6 条）
参考文献
Clarke, Kenneth; Fox, William Richard; Scrowston, Richard M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1029 - 1037
反应条件
1: 89 percent / n-butyl-lithium / diethyl ether / 1.) reflux, 2 h, 2.) - 70 deg C
2: SOCl2
4: 94 percent / bromine / CCl4 / 5 h / Heating; Irradiation
5: 90 percent / H2SO4 / 4 h
View Scheme
参考文献
Clarke, Kenneth; Fox, William Richard; Scrowston, Richard M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1029 - 1037
反应条件
1: SOCl2
3: 94 percent / bromine / CCl4 / 5 h / Heating; Irradiation
4: 90 percent / H2SO4 / 4 h
View Scheme
参考文献
Clarke, Kenneth; Fox, William Richard; Scrowston, Richard M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1029 - 1037
反应条件
2: 94 percent / bromine / CCl4 / 5 h / Heating; Irradiation
3: 90 percent / H2SO4 / 4 h
View Scheme
参考文献
Clarke, Kenneth; Fox, William Richard; Scrowston, Richard M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1029 - 1037
反应条件
1: 94 percent / bromine / CCl4 / 5 h / Heating; Irradiation
2: 90 percent / H2SO4 / 4 h
View Scheme
参考文献
Clarke, Kenneth; Fox, William Richard; Scrowston, Richard M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1029 - 1037
反应条件
1: 92 percent / NH2OH / ethanol / 2 h / 0 °C
2: 79 percent / NaHS, DMSO / acetone / 2 h / Heating
3: 74 percent / dimethylsulfoxide / 0.08 h / 170 °C / other 2,3-disubstituted thiophens; various conditions
View Scheme
参考文献
Clarke, Kenneth; Fox, William Richard; Scrowston, Richard M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1029 - 1037
