in diethylene glycol T=200°C; 0.5 h;

1: 89 percent / n-butyl-lithium / diethyl ether / 1.) reflux, 2 h, 2.) - 70 deg C 2: SOCl2 4: 94 percent / bromine / CCl4 / 5 h / Heating; Irradiation 5: 90 percent / H2SO4 / 4 h 6: 92 percent / NH2OH / ethanol / 2 h / 0 °C 7: 79 percent / NaHS, DMSO / acetone / 2 h / Heating 8: 74 percent / dimethylsulfoxide / 0.08 h / 170 °C / other 2,3-disubstituted thiophens; various conditions View Scheme

1: SOCl2 3: 94 percent / bromine / CCl4 / 5 h / Heating; Irradiation 4: 90 percent / H2SO4 / 4 h 5: 92 percent / NH2OH / ethanol / 2 h / 0 °C 6: 79 percent / NaHS, DMSO / acetone / 2 h / Heating 7: 74 percent / dimethylsulfoxide / 0.08 h / 170 °C / other 2,3-disubstituted thiophens; various conditions View Scheme

2: 94 percent / bromine / CCl4 / 5 h / Heating; Irradiation 3: 90 percent / H2SO4 / 4 h 4: 92 percent / NH2OH / ethanol / 2 h / 0 °C 5: 79 percent / NaHS, DMSO / acetone / 2 h / Heating 6: 74 percent / dimethylsulfoxide / 0.08 h / 170 °C / other 2,3-disubstituted thiophens; various conditions View Scheme

1: 94 percent / bromine / CCl4 / 5 h / Heating; Irradiation 2: 90 percent / H2SO4 / 4 h 3: 92 percent / NH2OH / ethanol / 2 h / 0 °C 4: 79 percent / NaHS, DMSO / acetone / 2 h / Heating 5: 74 percent / dimethylsulfoxide / 0.08 h / 170 °C / other 2,3-disubstituted thiophens; various conditions View Scheme

1: 92 percent / NH2OH / ethanol / 2 h / 0 °C 2: 79 percent / NaHS, DMSO / acetone / 2 h / Heating 3: 74 percent / dimethylsulfoxide / 0.08 h / 170 °C / other 2,3-disubstituted thiophens; various conditions View Scheme

1: 90 percent / H2SO4 / 4 h 2: 92 percent / NH2OH / ethanol / 2 h / 0 °C 3: 79 percent / NaHS, DMSO / acetone / 2 h / Heating 4: 74 percent / dimethylsulfoxide / 0.08 h / 170 °C / other 2,3-disubstituted thiophens; various conditions View Scheme

1: 79 percent / NaHS, DMSO / acetone / 2 h / Heating 2: 74 percent / dimethylsulfoxide / 0.08 h / 170 °C / other 2,3-disubstituted thiophens; various conditions View Scheme

1: 68 percent / NH2OH*HCl, NaOAc / ethanol / 1 h / 0 °C 2: 66 percent / bis-(2-hydroxy-ethyl) ether / 0.5 h / 200 °C View Scheme

1: acetone / 2 h / Ambient temperature 2: 68 percent / NH2OH*HCl, NaOAc / ethanol / 1 h / 0 °C 3: 66 percent / bis-(2-hydroxy-ethyl) ether / 0.5 h / 200 °C View Scheme