1.1: tetrafluoroboric acid; sodium nitrite / water / 3 h / 0 - 20 °C 1.2: 2 h / 20 °C 2.1: trifluoroacetic acid / chloroform / 6 h / |Reflux 3.1: tris-(dibenzylideneacetone)dipalladium(0); dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine / N,N-dimethyl-formamide; water / 0.67 h / 140 °C / |Inert atmosphere; |Microwave irradiation 4.1: hydrogenchloride / ethanol / 20 °C View Scheme

1: trifluoroacetic acid / chloroform / 6 h / |Reflux 2: tris-(dibenzylideneacetone)dipalladium(0); dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine / N,N-dimethyl-formamide; water / 0.67 h / 140 °C / |Inert atmosphere; |Microwave irradiation 3: hydrogenchloride / ethanol / 20 °C View Scheme

hydrogenchloride; sodium cyanide; sodium nitrite Multistep reaction;

N-bromosuccinmide in N,N-dimethyl-formamide T=20°C; 2 h;

1: With lithium aluminium tetrahydride in tetrahydrofuran 2 h; 2: With lithium hydroxide in tetrahydrofuran; water

sodium hydroxide in tetrahydrofuran; water

pyridine; nickel monoaluminide in water; acetic acid

sulfuric acid; water in acetic acid T=100°C; 3 h;

iodine; potassium hydroxide in N,N-dimethyl-formamide T=0 - 20°C; 2.5 h; regioselective reaction;