alpha-(甲基氨基)-苯乙酸合成路线 （共 27 条）
反应条件
Carbonate buffer controlled potential electrolysis: glassy-carbon plate electrode, pH 10; Product distribution;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 32, # 12 p. 4740 - 4745
反应条件
1: 90 percent / Ac2O / 100 °C 2: 77 percent / xylene / Heating 3: 93 percent / 10percent aq. NaOH / 14 h / Heating 4: 96 percent / diphenyl ether / Heating 5: 95 percent / Br2 / CHCl3 / Ambient temperature 6: 1) n-BuLi / 1) ether, hexane, -35 to -30 deg C then RT, 15 h, 2) THF,ether, hexane, -30 to 25 deg C, overnight View Scheme
参考文献
Kano, Kunio; Scarpetti, David; Warner, John C.; Anselme, Jean-Pierre; Springer, James H.; Arison, Byron H.
Canadian Journal of Chemistry, 1986 , vol. 64, p. 2211 - 2219
反应条件
Carbonate buffer controlled potential electrolysis: glassy-carbon plate electrode, pH 10; Product distribution;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 32, # 12 p. 4740 - 4745
反应条件
1: 90 percent / Ac2O / 100 °C 2: 77 percent / xylene / Heating 3: 93 percent / 10percent aq. NaOH / 14 h / Heating 4: 96 percent / diphenyl ether / Heating View Scheme
参考文献
Kano, Kunio; Scarpetti, David; Warner, John C.; Anselme, Jean-Pierre; Springer, James H.; Arison, Byron H.
Canadian Journal of Chemistry, 1986 , vol. 64, p. 2211 - 2219
反应条件
acetic anhydride T=100°C;
参考文献
Kano, Kunio; Scarpetti, David; Warner, John C.; Anselme, Jean-Pierre; Springer, James H.; Arison, Byron H.
Canadian Journal of Chemistry, 1986 , vol. 64, p. 2211 - 2219
反应条件
formic acid 4 h; Heating;
参考文献
Shiraiwa, Tadashi; Baba, Yoshihisa; Miyazaki, Hideya; Sakata, Shinji; Kawamura, Seiko; et al.
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 5 p. 1430 - 1437
反应条件
1: 2-amino-2-phenylacetic acid With sodium carbonate; sodium hydroxide
0.5 h;
2: chloroformic acid ethyl ester in dichloromethane
T=20°C; 2 h;
参考文献
GRUENENTHAL GmbH
Patent: US2010/173889 A1, 2010 ;
Location in patent: Page/Page column 33 ;
反应条件
in methanol
T=20°C; 3 h;
参考文献
Shiraiwa, Tadashi; Baba, Yoshihisa; Miyazaki, Hideya; Sakata, Shinji; Kawamura, Seiko; et al.
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 5 p. 1430 - 1437
反应条件
hydrogenchloride; acetic acid
参考文献
Sheehan et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 3349,3353
反应条件
1: aqueous NaOH
2: aqueous HCl; acetic acid
View Scheme
参考文献
Sheehan et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 3349,3353
