alpha-(甲基氨基)-苯乙酸合成路线 （共 27 条）
反应条件
2: aqueous NaOH
3: aqueous HCl; acetic acid
View Scheme
参考文献
Sheehan et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 3349,3353
反应条件
water in methanol; toluene
8 h; Heating;
参考文献
De Athayde-Filho, Petronio Filgueiras; Miller, Joseph; Simas, Alfredo Mayall; Lira, Bruno Freitas; De Souza Luis, Jose Alixandre; Zuckerman-Schpector, Julio
Synthesis, 2003 , # 5 p. 685 - 690
反应条件
1: aq. methanol / 2 h
2: 25.30 g / H2O / methanol; toluene / 8 h / Heating
View Scheme
参考文献
De Athayde-Filho, Petronio Filgueiras; Miller, Joseph; Simas, Alfredo Mayall; Lira, Bruno Freitas; De Souza Luis, Jose Alixandre; Zuckerman-Schpector, Julio
Synthesis, 2003 , # 5 p. 685 - 690
反应条件
1: 1.) NH3 / 1.) ether, 1 h 2.) CH2Cl2, room temp., overnight.
2: 2.) aq. HCl / 1.) toluene, reflux, 1 h 2.) reflux, 1 h
View Scheme
参考文献
O'Donnell, Martin J.; Bruder, William A.; Daugherty, Byron W.; Liu, Deshan; Wojciechowski, Krzisztof
Tetrahedron Letters, 1984 , vol. 25, # 34 p. 3651 - 3654
反应条件
hydrogenchloride
1.) toluene, reflux, 1 h 2.) reflux, 1 h; Yield given. Multistep reaction;
参考文献
O'Donnell, Martin J.; Bruder, William A.; Daugherty, Byron W.; Liu, Deshan; Wojciechowski, Krzisztof
Tetrahedron Letters, 1984 , vol. 25, # 34 p. 3651 - 3654
参考文献
Tiemann; Piest
Chemische Berichte, 1881 , vol. 14, p. 1982
反应条件
barium permanganate; mineral acid
参考文献
Knoop
Chemische Berichte, 1919 , vol. 52, p. 2269
反应条件
acetic acid; sodium nitrite
参考文献
LiBassi,G. et al.
Gazzetta Chimica Italiana, 1977 , vol. 107, p. 253 - 255
参考文献
Huisgen,R. et al.
Chemische Berichte, 1971 , vol. 104, p. 1532 - 1549
反应条件
2: 20 °C
3: barium permanganate; diluted mineral acid
View Scheme
参考文献
Knoop
Chemische Berichte, 1919 , vol. 52, p. 2269
