2-氯-5-羟基吡啶-3-甲腈合成路线 （共 7 条）
反应条件
pyridine hydrochloride
T=200°C; 2 h;
参考文献
Ponticello, Gerald S.; Engelhardt, Edward L.; Freedman, Mark B.; Baldwin, John J.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 445 - 448
参考文献
Merck and Co., Inc.
Patent: US4374140 A1, 1983 ;
US 4374140 A
反应条件
1: 95 percent / NaH / dimethylformamide / Ambient temperature; overnight
2: 35 percent / KMnO4 / H2O / 1 h / Heating
3: SOCl2 / 3 h / Heating
4: NH3*H2O / 0.25 h / 0 - 4 °C
5: 86 percent / triflic anhydride/triphenylphosphine oxide / CH2Cl2 / Ambient temperature; overnight
6: 70 percent / pyridine hydrochloride / 2 h / 200 °C
View Scheme
参考文献
Ponticello, Gerald S.; Engelhardt, Edward L.; Freedman, Mark B.; Baldwin, John J.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 445 - 448
反应条件
1: 35 percent / KMnO4 / H2O / 1 h / Heating
2: SOCl2 / 3 h / Heating
3: NH3*H2O / 0.25 h / 0 - 4 °C
4: 86 percent / triflic anhydride/triphenylphosphine oxide / CH2Cl2 / Ambient temperature; overnight
5: 70 percent / pyridine hydrochloride / 2 h / 200 °C
View Scheme
参考文献
Ponticello, Gerald S.; Engelhardt, Edward L.; Freedman, Mark B.; Baldwin, John J.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 445 - 448
反应条件
1: 86 percent / triflic anhydride/triphenylphosphine oxide / CH2Cl2 / Ambient temperature; overnight
2: 70 percent / pyridine hydrochloride / 2 h / 200 °C
View Scheme
参考文献
Ponticello, Gerald S.; Engelhardt, Edward L.; Freedman, Mark B.; Baldwin, John J.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 445 - 448
反应条件
1: SOCl2 / 3 h / Heating
2: NH3*H2O / 0.25 h / 0 - 4 °C
3: 86 percent / triflic anhydride/triphenylphosphine oxide / CH2Cl2 / Ambient temperature; overnight
4: 70 percent / pyridine hydrochloride / 2 h / 200 °C
View Scheme
参考文献
Ponticello, Gerald S.; Engelhardt, Edward L.; Freedman, Mark B.; Baldwin, John J.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 445 - 448
反应条件
1: 1.)NaNO2/12N HCl 2.)HPF6
2: 95 percent / NaH / dimethylformamide / Ambient temperature; overnight
3: 35 percent / KMnO4 / H2O / 1 h / Heating
4: SOCl2 / 3 h / Heating
5: NH3*H2O / 0.25 h / 0 - 4 °C
6: 86 percent / triflic anhydride/triphenylphosphine oxide / CH2Cl2 / Ambient temperature; overnight
7: 70 percent / pyridine hydrochloride / 2 h / 200 °C
View Scheme
参考文献
Ponticello, Gerald S.; Engelhardt, Edward L.; Freedman, Mark B.; Baldwin, John J.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 445 - 448
