(1r,2s)-1-氨基-2-乙烯-环丙烷羧酸乙酯合成路线 （共 4 条）
反应条件
1: With sulfuric acid; water in ethyl acetate
T=20 - 48°C; 1 h;
2: With triethylamine in ethyl acetate
T=18 - 30°C;
参考文献
Gantz, Francois; Stahr, Helmut
Patent: US2008/269502 A1, 2008 ;
Location in patent: Page/Page column 6 ;
反应条件
potassium hydrogencarbonate in water; ethyl acetate
T=6°C; 1 h;
参考文献
API Corporation
Patent: EP2537825 A1, 2012 ;
Location in patent: Page/Page column 33-34 ;
反应条件
1: in toluene
T=80°C; 3 h;
2: With sulfuric acid; water in acetone; toluene
T=20°C; 24 h;
3: With sodium hydroxide in water
参考文献
API Corporation
Patent: EP2537825 A1, 2012 ;
Location in patent: Page/Page column 31 ;
反应条件
1: phosphoric acid / tert-butyl methyl ether; methanol / 2 h / 20 °C
2: sodium hydroxide / water / 35 °C / pH 8.15 / Resolution of racemate; Enzymatic reaction
View Scheme
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; TAYLOR, Ian N.; LLOYD, Michael C.; HESELTINE, Adrian
Patent: WO2011/3063 A2, 2011 ;
