sodium hydrogencarbonate in 1,4-dioxane; water T=20°C; 22 h;

1: water / 100 °C 2: palladium 10 on activated carbon; hydrogen / methanol / 9 h / 20 °C 3: hydrogenchloride; water / 3 h / Reflux 4: sodium hydrogencarbonate / 1,4-dioxane; water / 22 h / 20 °C View Scheme

1: sodium acetate; acetic anhydride / 0.02 h / 20 - 100 °C 2: water / 100 °C 3: palladium 10 on activated carbon; hydrogen / methanol / 9 h / 20 °C 4: hydrogenchloride; water / 3 h / Reflux 5: sodium hydrogencarbonate / 1,4-dioxane; water / 22 h / 20 °C View Scheme

1: hydrogenchloride; water / 3 h / Reflux 2: sodium hydrogencarbonate / 1,4-dioxane; water / 22 h / 20 °C View Scheme

1: chloro-trimethyl-silane / 36 h / 40 °C 2: ammonium hydroxide; α-chymotrypsine; ammonium acetate / water; N,N-dimethyl-formamide / 2 h / 20 °C / pH 6.9 / Enzymatic reaction View Scheme