(1,1-二甲基-2-丙炔)-苯胺合成路线 （共 15 条）
反应条件
1: 77 percent / CaCl2; aq. HCl; Cu/bronze / Cu(I)Cl / 48 h / 20 °C
2: 79 percent / Et3N; H2O; Cu/bronze / Cu(I)Cl / tetrahydrofuran / 4 h / 60 - 70 °C
View Scheme
参考文献
Cooper; Lucas; Taylor; Ward; Williamson
Synthesis, 2001 , # 4 p. 621 - 625
反应条件
1: Et3N, DMAP / CH2Cl2 / 2 h / Ambient temperature
2: CuCl, Et3N / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
反应条件
triethylamine; copper(l) chloride in tetrahydrofuran
3 h; Heating; Yield given;
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
反应条件
1: 74 percent / CuCl / tetrahydrofuran / 14 h / Heating
2: 99 percent / H2 / 10percent Pd/C / ethanol; ethyl acetate / 4 h
View Scheme
参考文献
Partali, Vassilia; Jolidon, Synese; Hansen, Hans-Juergen
Helvetica Chimica Acta, 1985 , vol. 68, p. 1952 - 1960
反应条件
hydrogen; Lindlar's catalyst in diethyl ether
T=20°C;
参考文献
Cooper; Lucas; Taylor; Ward; Williamson
Synthesis, 2001 , # 4 p. 621 - 625
