2-(4-溴苯氧基)-2-甲基丙酸合成路线 （共 11 条）
反应条件
1: With sodium hydroxide T=20 - 35°C; 21.5 h; Heating / reflux; 2: With hydrogenchloride in water T=0°C;
参考文献
BIOLIPOX AB
Patent: WO2005/123673 A1, 2005 ;
Location in patent: Page/Page column 61 ;
WO 2005/123673 A1
反应条件
sodium hydroxide in acetone 16 h; Ambient temperature;
参考文献
Clewley, Robin G.; Fischer, Alfred; Henderson, George N.
Canadian Journal of Chemistry, 1989 , vol. 67, p. 1472 - 1479
反应条件
1: 4-bromo-phenol; acetone With potassium hydroxide in water T=20°C; 0.5 h; 2: tribromo methane in water T=20°C; 3: With hydrogenchloride in water
参考文献
Porcelli; Gilardi; Laghezza; Piemontese; Mitro; Azzariti; Altieri; Cervoni; Fracchiolla; Giudici; Guerrini; Lavecchia; Montanari; Di Giovanni; Paradiso; Pochetti; Simone; Tortorella; Crestani; Loiodice
Journal of Medicinal Chemistry, 2012 , vol. 55, # 1 p. 37 - 54
反应条件
sodium hydroxide; chloroform; acetone
参考文献
Journal of the American Chemical Society, , vol. 77, p. 6644
Acta Chemica Scandinavica (1947-1973), , vol. 7, p. 596,599
反应条件
Multistep reaction.;
参考文献
Journal of the Chinese Chemical Society, , vol. 54, # 3 p. 575 - 578
反应条件
ammonia; nitric acid; trifluoroacetic anhydride 1.) acetic anhydride, -60 deg C; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given;
参考文献
Clewley, Robin G.; Fischer, Alfred; Henderson, George N.
Canadian Journal of Chemistry, 1989 , vol. 67, p. 1472 - 1479
反应条件
in tetrahydrofuran; methyl-magnesium iodide; benzonitrile
参考文献
Orchimed S.A.
Patent: US4072705 A1, 1978 ;
反应条件
(i) MeMgI, THF, (ii) /BRN= 506893/; Multistep reaction;
参考文献
Labor. Fournier
Patent: FR2300552DE2605382 , 19761976 ;
Chem.Abstr., 1976 , vol. 85, # 192382
反应条件
thionyl chloride
Behandeln des Reaktionsprodukts mit Ammoniak in Benzol;
参考文献
Gilman; Wilder
Journal of the American Chemical Society, 1955 , vol. 77, p. 6644
反应条件
thionyl chloride
T=20°C; 6 h; Heating / reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2009/52078 A1, 2009 ;
Location in patent: Page/Page column 66 ;
WO 2009/052078 A1
