2-羟基-2-甲基-1-苯基-1-丙酮合成路线 （共 64 条）
反应条件
1: (i) benzene, (ii) (heating) 2: LiAlH4 / tetrahydrofuran View Scheme
参考文献
Hofmann,H. et al.
Chemische Berichte, 1971 , vol. 104, p. 2134 - 2142
反应条件
Al tri-t-BuO- in toluene T=80°C; Equilibrium constant;
参考文献
Brunner, Henri; Stoehr, Frank
European Journal of Organic Chemistry, 2000 , # 15 p. 2777 - 2786
反应条件
(i) benzene, (ii) (heating); Multistep reaction;
参考文献
Hofmann,H. et al.
Chemische Berichte, 1971 , vol. 104, p. 2134 - 2142
反应条件
in acetonitrile-D3 T=20°C; Irradiation; Mechanism;
参考文献
Yankelevich, A. Z.; Potapov, V. K.; Hagemann, H. J.; Kuznets, V. K.; Pershin, A. D.; Buchachenko, A. L.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1982 , vol. 31, # 3 p. 460 - 466
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1982 , # 3 p. 513 - 521
反应条件
1.1: p-toluenesulfonic acid monohydrate / toluene / 24 h / Heating 2.1: sodium borohydride; acetic acid / tetrahydrofuran / 0 - 20 °C 2.2: HCl / hexane; dioxane / 4 h / 20 °C 2.3: Et3N / 1,2-dichloro-ethane / 6 h / Heating 3.1: 84 percent / TfOH; anisole / toluene / 3 h View Scheme
参考文献
Sugiyama, Shigeo; Arai, Satoshi; Ishii, Keitaro
Heterocycles, 2005 , vol. 65, # 1 p. 149 - 159
反应条件
triethylamine in dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
Cutulic, Sylvain P. Y.; Findlay, Neil J.; Zhou, Sheng-Ze; Chrystal, Ewan J. T.; Murphy, John A.
Journal of Organic Chemistry, 2009 , vol. 74, # 22 p. 8713 - 8718
反应条件
1: Et3N / -78 - 0 °C 2: 85percent m-chloroperbenzoic acid / CH2Cl2 View Scheme
参考文献
Creary,X.; Geiger,C.C.
Journal of the American Chemical Society, 1982 , vol. 104, p. 4151
反应条件
1.1: n-butyllithium / hexane; diethyl ether / 2 h / -78 - -20 °C 1.2: -78 - 20 °C 2.1: silver trifluoromethanesulfonate / toluene / 0.5 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Egi, Masahiro; Ota, Yuya; Nishimura, Yuka; Shimizu, Kaori; Azechi, Kenji; Akai, Shuji
Organic Letters, 2013 , vol. 15, # 16 p. 4150 - 4153
反应条件
1: p-toluenesulfonic acid monohydrate / toluene / 24 h / Heating View Scheme
参考文献
Sugiyama, Shigeo; Arai, Satoshi; Ishii, Keitaro
Heterocycles, 2005 , vol. 65, # 1 p. 149 - 159
反应条件
nonafluoro-n-butanesulfonyl fluoride; triethylamine tris(hydrogen fluoride); triethylamine in acetonitrile
T=95°C; 9 h;
参考文献
Yin, Jingjun; Zarkowsky, Devin S.; Thomas, David W.; Zhao, Matthew M.; Huffman, Mark A.
Organic Letters, 2004 , vol. 6, # 9 p. 1465 - 1468
