3-氟-4-醛基苯甲酸甲酯合成路线 （共 11 条）
反应条件
1: 3-fluoro-4-formylbenzoic acid With sodium hydride in N,N-dimethyl-formamide
0.5 h;
2: methyl iodide in N,N-dimethyl-formamide
T=20°C; 15 h;
参考文献
SCHERING CORPORATION
Patent: WO2008/130584 A1, 2008 ;
Location in patent: Page/Page column 144-145 ;
WO 2008/130584 A1
反应条件
dimethyl sulfoxide in hexane; dichloromethane; water; ethyl acetate
参考文献
SANKYO COMPANY, LIMITED
Patent: US2003/176480 A1, 2003 ;
反应条件
1: With N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane
T=100°C; 20 h;
2: With silver nitrate in water; acetone
24 h; Darkness;
参考文献
Cheung, Adrian Wai-Hing; Guertin, Kevin Richard; Haynes, Nancy-Ellen; Mertz, Eric; Qi, Lida; Qian, Yimin; Scott, Nathan Robert
Patent: US2012/258982 A1, 2012 ;
Location in patent: Page/Page column 53 ;
US 20120258982 A1
反应条件
bis-triphenylphosphine-palladium(II) chloride; carbon monoxide in N,N-dimethyl-formamide
T=110°C; 2 h;
参考文献
Zimmerman, Sommer S.; Khatri, Alpa; Garnier-Amblard, Ethel C.; Mullasseril, Praseeda; Kurtkaya, Natalie L.; Gyoneva, Stefka; Hansen, Kasper B.; Traynelis, Stephen F.; Liotta, Dennis C.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2334 - 2356
参考文献
Beecham Group Limited
Patent: US4478849 A1, 1984 ;
反应条件
1: 72 percent / K2CO3 / acetone / Heating
2: NBS; AIBN / CCl4 / Heating
3: 1.94 g / AgNO3; H2O / acetone
View Scheme
参考文献
Gauuan, Polivina Jolicia F; Trova, Michael P; Gregor-Boros, Livia; Bocckino, Stephen B; Crapo, James D; Day, Brian J
Bioorganic and medicinal chemistry, 2002 , vol. 10, # 9 p. 3013 - 3021
反应条件
1: NBS; AIBN / CCl4 / Heating
2: 1.94 g / AgNO3; H2O / acetone
View Scheme
参考文献
Gauuan, Polivina Jolicia F; Trova, Michael P; Gregor-Boros, Livia; Bocckino, Stephen B; Crapo, James D; Day, Brian J
Bioorganic and medicinal chemistry, 2002 , vol. 10, # 9 p. 3013 - 3021
反应条件
1.1: silver nitrate / ethanol; water / 0.75 h / 50 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 20 °C
2.2: 5 h / 20 °C
View Scheme
参考文献
Almirall, S.A.
Patent: EP2526945 A1, 2012 ;
EP 2526945 A1
反应条件
1: methanol; tetrahydrofuran / 1 h / 0 - 20 °C
2: bis-triphenylphosphine-palladium(II) chloride; carbon monoxide / N,N-dimethyl-formamide / 2 h / 110 °C
View Scheme
参考文献
Zimmerman, Sommer S.; Khatri, Alpa; Garnier-Amblard, Ethel C.; Mullasseril, Praseeda; Kurtkaya, Natalie L.; Gyoneva, Stefka; Hansen, Kasper B.; Traynelis, Stephen F.; Liotta, Dennis C.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2334 - 2356
反应条件
1.1: potassium carbonate / ethyl acetate; acetone / 175.2 h / 25 - 90 °C
2.1: 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / tetrachloromethane / 20 h / 100 °C
2.2: 24 h / Darkness
View Scheme
参考文献
Cheung, Adrian Wai-Hing; Guertin, Kevin Richard; Haynes, Nancy-Ellen; Mertz, Eric; Qi, Lida; Qian, Yimin; Scott, Nathan Robert
Patent: US2012/258982 A1, 2012 ;
US 20120258982 A1
