4-溴甲基-2-甲基苯甲酸甲酯合成路线 （共 15 条）
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C 1.2: 18 h / 20 °C 2.1: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / tetrachloromethane / 8 h / 70 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 22 p. 6768 - 6778
参考文献
Bulletin de la Societe Chimique de France, , p. 2255 - 2261
反应条件
potassium hydroxide in water
参考文献
G. D. Searle and Co.
Patent: US5302601 A1, 1994 ;
US 5302601 A
反应条件
(i) hexamethylenetetramine, (ii) aq. AcOH; Multistep reaction;
参考文献
Itoh, Yukihiro; Kitaguchi, Risa; Ishikawa, Minoru; Naito, Mikihiko; Hashimoto, Yuichi
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 22 p. 6768 - 6778
反应条件
sodium methylate; sodium in methanol
参考文献
Beecham Group Limited
Patent: US4478849 A1, 1984 ;
