1-(3-溴苯基)-4-甲基-哌嗪合成路线 （共 5 条）
反应条件
2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium t-butanolate; bis(dibenzylideneacetone)-palladium(0) in toluene
T=60 - 100°C;
参考文献
VERNALIS (CAMBRIDGE) LIMITED; CANCER RESEARCH TECHNOLOGY LTD; THE INSTITUTE OF CANCER RESEARCH
Patent: WO2004/72051 A1, 2004 ;
Location in patent: Page 55 ;
反应条件
1: 1-(3-bromophenyl)-4-methylpiperazine With n-butyllithium in tetrahydrofuran; hexane
T=-78 - -70°C;
2: tri-isopropoxy-borane in tetrahydrofuran; hexane
T=-78 - 20°C;
3: With water; ammonium chloride in tetrahydrofuran; hexane
参考文献
SENEXIS LIMITED; HORWELL, David Christopher; SCOPES, David Ian Carter
Patent: WO2011/144578 A1, 2011 ;
Location in patent: Page/Page column 34 ;
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-70 - -65°C; 1 h;
2: With tri-isopropoxy-borane in tetrahydrofuran; hexane
T=-70 - 20°C;
3: With water; ammonium chloride in tetrahydrofuran; hexane
参考文献
SENEXIS LIMITED
Patent: US2010/298325 A1, 2010 ;
Location in patent: Page/Page column 22 ;
反应条件
triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in dichloromethane; toluene
T=100°C; 1 h; Irradiation;
参考文献
VERNALIS (CAMBRIDGE) LIMITED; CANCER RESEARCH TECHNOLOGY LTD; THE INSTITUTE OF CANCER RESEARCH
Patent: WO2004/72051 A1, 2004 ;
Location in patent: Page 56 ;
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in 1,4-dioxane
T=90°C; 3 h;
参考文献
MERCK PATENT GMBH; EGGENWEILER, Hans-Michael; HOELZEMANN, Guenter; DORSCH, Dieter
Patent: WO2013/117285 A1, 2013 ;
Location in patent: Page/Page column 83; 84 ;
