4-(4-甲基-1-哌嗪基)苯硼酸频哪醇酯合成路线 （共 5 条）
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in toluene Inert atmosphereReflux;
参考文献
PROZYMEX A/S; PEDERSEN, John; LAURITZEN, Conni
Patent: WO2012/130299 A1, 2012 ;
Location in patent: Page/Page column 149 ;
WO 2012/130299 A1
反应条件
1: 1-bromo-4-(4-methyl-1-piperazinyl)benzene With tert.-butyl lithium in tetrahydrofuran T=-78°C; 0.25 h; 2: 2,3-dimethylbutane-2,3-diol With tri-isopropoxy-borane in tetrahydrofuran T=20°C; 3 h;
参考文献
Andersen, Valdemar L.; Herth, Matthias M.; Lehel, Szabolcs; Knudsen, Gitte M.; Kristensen, Jesper L.
Tetrahedron Letters, 2013 , vol. 54, # 3 p. 213 - 216
反应条件
1: 1-bromo-4-(4-methyl-1-piperazinyl)benzene With n-butyllithium in tetrahydrofuran; hexanes T=-78°C; 1 h; 2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran; hexanes T=-78 - 20°C;
参考文献
WO2008/148867 A2, ;
Page/Page column 49-50 ;
WO 2008/148867 A2
反应条件
1: triethylamine / ethanol / 80 h / Reflux 2: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene / Inert atmosphere; Reflux View Scheme
参考文献
WO2012/130299 A1, ;
WO 2012/130299 A1
反应条件
1: triethylamine / ethanol / 80 h / Reflux 2: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene / Inert atmosphere; Reflux View Scheme
参考文献
WO2012/130299 A1, ;
WO 2012/130299 A1
