4,4'-(1,3-丙烷二基二氧基)二苯甲腈合成路线 （共 11 条）
反应条件
1: HCl (gas) / benzene / 72 h / Ambient temperature 2: ethanol. NH3 / 6 h / 50 °C View Scheme
参考文献
Tidwell; Jones; Geratz; Ohemeng; Cory; Hall
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1252 - 1257
参考文献
Oxley; Short
Journal of the Chemical Society, 1946 , p. 147,149
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Oxley; Partridge; Short
Journal of the Chemical Society, 1948 , p. 303,308
参考文献
Partridge; Short
Journal of the Chemical Society, 1947 , p. 390,391
反应条件
hydrogenchloride; potassium carbonate in water; ethyl acetate; N,N-dimethyl-formamide
参考文献
Array Biopharma Inc.
Patent: US6221914 B1, 2001 ;
US 6221914 B1
反应条件
sodium hydride in tetrahydrofuran; dimethyl sulfoxide
T=0 - 20°C;
参考文献
Vazquez, Olalla; Sanchez, Mateo I.; Martinez-Costas, Jose; Vazquez, M. Eugenlo; Mascarenas, Jose L.
Organic Letters, 2010 , vol. 12, # 2 p. 216 - 219
反应条件
phosphorus pentachloride
T=190°C;
参考文献
Miller
Org. Synth. Coll. Vol., 1955 , vol. III, p. 646,648
反应条件
1: ethanolic NaOH
2: aqueous sodium sulfide
3: ueber die Diazonium-Verbindung dargestellt
View Scheme
参考文献
Partridge; Short
Journal of the Chemical Society, 1947 , p. 390,391
反应条件
1: aqueous sodium sulfide
2: ueber die Diazonium-Verbindung dargestellt
View Scheme
参考文献
Partridge; Short
Journal of the Chemical Society, 1947 , p. 390,391
参考文献
Ashley et al.
Journal of the Chemical Society, 1942 , p. 103,107
参考文献
Berg; Newbery
Journal of the Chemical Society, 1949 , p. 642,645
