N-(2-氨基乙基)-N-吡啶-2-胺合成路线 （共 13 条）
反应条件
in pyridine 5 h; Heating;
参考文献
European Journal of Medicinal Chemistry, , vol. 22, p. 91 - 100
反应条件
di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; Py2NP(i-Pr)2; sodium t-butanolate in tetrahydrofuran; diethylene glycol dimethyl ether T=110°C; 24 h; Inert atmosphere; chemoselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 351, # 17 p. 2903 - 2911
反应条件
pyridine in water; ethylenediamine
反应条件
Inert atmosphereReflux;
参考文献
Organic and Biomolecular Chemistry, , vol. 6, # 16 p. 2978 - 2981
参考文献
US2003/125339 A1, ;
US6878714 B2, ;
US 6878714 B2
参考文献
US2003/225106 A1, ;
Page 116 ;
反应条件
in water; dimethyl sulfoxide
反应条件
1: 71 percent / sodium hydride / dimethylsulfoxide / 1.) below 40 deg C, 20 min, 2.) 22 deg C, 45 min 2: 91 percent / acetic anhydride / diethyl ether / 16 h / 22 °C 3: 95 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 4: 79 percent / potassium carbonate / dimethylformamide / 2 h / 100 °C 5: 86 percent / LiAlH4 / diethyl ether / 18 h / 22 °C View Scheme
参考文献
Blakemore, Robert C.; Ganellin, C. Robin; Garbarg, Monique; Gros, Claude; Ife, Robert J.; et al.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 91 - 100
反应条件
1: 71 percent / sodium hydride / dimethylsulfoxide / 1.) below 40 deg C, 20 min, 2.) 22 deg C, 45 min 2: 91 percent / acetic anhydride / diethyl ether / 16 h / 22 °C 3: 95 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 4: 79 percent / potassium carbonate / dimethylformamide / 2 h / 100 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 22, p. 91 - 100
反应条件
1: 71 percent / sodium hydride / dimethylsulfoxide / 1.) below 40 deg C, 20 min, 2.) 22 deg C, 45 min 2: 91 percent / acetic anhydride / diethyl ether / 16 h / 22 °C 3: 95 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Sadek, Bassem; Alisch, Rudi; Buschauer, Armin; Elz, Sigurd
Molecules, 2013 , vol. 18, # 11 p. 14186 - 14202
