3-(1H-吡洛-1-基）噻吩-2-羧酸合成路线 （共 4 条）
反应条件
sodium hydroxide 2.5 h; Heating;
参考文献
Adir et Compagnie
Patent: US5627203 A1, 1997 ;
反应条件
1: AcOH / 2 h / Heating 2: NaOH / H2O; methanol / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 10 p. 2068 - 2080
反应条件
sodium azide; triethylamine in water; acetone
T=0°C; 1.5 h;
参考文献
Rault, Sylvain; Effi, Yamien; Sevricourt, Michel Cugnon de; Lancelot, Jean-Charles; Robba, Max
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 17 - 21
反应条件
sodium azide; TEA; chloroformic acid ethyl ester in acetone; acetonitrile
T=0°C;
参考文献
Lemaitre, Stephane; Lepailleur, Alban; Bureau, Ronan; Butt-Gueulle, Sabrina; Lelong-Boulouard, Veronique; Duchatelle, Pascal; Boulouard, Michel; Dumuis, Aline; Daveu, Cyril; Lezoualc'h, Frank; Pfeiffer, Bruno; Dauphin, Francois; Rault, Sylvain
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 6 p. 2607 - 2622
