5-(4-羟基苄基)噻唑烷-2,4-二酮合成路线 （共 14 条）
反应条件
ammonium formate; Pd on carbon in acetic acid; ethyl acetate
参考文献
Neogi, Partha; Dey, Debendranath; Medicherla, Satyanarayana; Nag, Bishwajit; Lee, Arthur
Patent: US2003/181494 A1, 2003 ;
反应条件
boron tribromide in dichloromethane; water
反应条件
acetic acid; zinc in ethyl acetate T=25 - 35°C; 9 h; Product distribution / selectivity;
参考文献
CADILA HEALTHCARE LIMITED
Patent: WO2004/7490 A2, 2004 ;
Location in patent: Page 39 ;
反应条件
1.1: HBr; NaNO2 1.2: methanol 2.1: HCl View Scheme
参考文献
Pharmazie, , vol. 59, # 11 p. 836 - 839
反应条件
1: piperidine; AcOH / toluene / 4 h / Heating 2: 43 percent / CoCl2; DMG; NaBH4 / NaOH / tetrahydrofuran; H2O / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 10 p. 2547 - 2550
反应条件
acetic acid; zinc in methanol Industry scale; Product distribution / selectivity;
参考文献
WO2004/7490 A2, ;
Page 44 ;
反应条件
1: thionyl chloride / chloroform / 1 h / |Reflux 2: acetic acid; piperidine / toluene / |Heating 3: hydrogen / tetrahydrofuran / 12 h 4: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme
反应条件
1.1: Raney nickel / methanol 2.1: HBr; NaNO2 2.2: methanol 3.1: HCl View Scheme
参考文献
Pharmazie, , vol. 59, # 11 p. 836 - 839
反应条件
1: thionyl chloride / chloroform / 2 h / |Reflux 2: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme
反应条件
hydrogenchloride 1.) sulfolane, 120 deg C, 10 h; 2.) sulfolane, 100 deg C, 8 h; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 30, # 10 p. 3580 - 3600
