(6Z,9Z,11E,13S)-13-羟基十八碳-6,9,11-三烯酸合成路线 （共 18 条）
反应条件
1.1: acetonitrile / Heating
2.1: NaHMDS; HMPA / tetrahydrofuran / 1 h / -30 °C
2.2: 38 percent / tetrahydrofuran / -30 - 20 °C
3.1: 60 percent / Li; liq. NH3 / tetrahydrofuran / 2 h / cooling
View Scheme
参考文献
Nanda; Yadav
Tetrahedron Asymmetry, 2003 , vol. 14, # 13 p. 1799 - 1806
反应条件
1.1: n-BuLi; HMPA / tetrahydrofuran; hexane / 1 h / 0 °C
1.2: tetrahydrofuran; hexane / 0 °C
2.1: PTSA / methanol / 1 h / 20 °C
3.1: Jones reagent / acetone / 0 - 20 °C
4.1: 60 percent / Li; liq. NH3 / tetrahydrofuran / 2 h / cooling
View Scheme
参考文献
Nanda; Yadav
Tetrahedron Asymmetry, 2003 , vol. 14, # 13 p. 1799 - 1806
反应条件
1.1: NaHMDS; HMPA / tetrahydrofuran / 1 h / -30 °C
1.2: 38 percent / tetrahydrofuran / -30 - 20 °C
2.1: 60 percent / Li; liq. NH3 / tetrahydrofuran / 2 h / cooling
View Scheme
参考文献
Nanda; Yadav
Tetrahedron Asymmetry, 2003 , vol. 14, # 13 p. 1799 - 1806
反应条件
1.1: NaHMDS; HMPA / tetrahydrofuran / 1 h / -30 °C
1.2: 38 percent / tetrahydrofuran / -30 - 20 °C
2.1: 60 percent / Li; liq. NH3 / tetrahydrofuran / 2 h / cooling
View Scheme
参考文献
Nanda; Yadav
Tetrahedron Asymmetry, 2003 , vol. 14, # 13 p. 1799 - 1806
反应条件
1.1: 0.6 g / acetonitrile / 48 h / 60 °C
2.1: n-BuLi; HMPA / tetrahydrofuran; hexane / 1 h / 0 °C
2.2: tetrahydrofuran; hexane / 0 °C
3.1: PTSA / methanol / 1 h / 20 °C
4.1: Jones reagent / acetone / 0 - 20 °C
5.1: 60 percent / Li; liq. NH3 / tetrahydrofuran / 2 h / cooling
View Scheme
参考文献
Nanda; Yadav
Tetrahedron Asymmetry, 2003 , vol. 14, # 13 p. 1799 - 1806
反应条件
1: Jones reagent / acetone / 0 - 20 °C
2: 60 percent / Li; liq. NH3 / tetrahydrofuran / 2 h / cooling
View Scheme
参考文献
Nanda; Yadav
Tetrahedron Asymmetry, 2003 , vol. 14, # 13 p. 1799 - 1806
反应条件
sodium tetrahydroborate
Yield given;
参考文献
Haviv; Ratajczyk; DeNet; Martin; Dyer; Carter
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 254 - 263
反应条件
1: 50percent (NH4)2SO4 / soybean lipoxygenase
2: NaBH4
View Scheme
参考文献
Haviv; Ratajczyk; DeNet; Martin; Dyer; Carter
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 254 - 263
