2-氨基-5-三氟甲基吡啶合成路线 （共 20 条）
反应条件
copper(I) oxide; potassium carbonate; ammonium hydroxide; N,N-dimethylethylenediamine in ethylene glycol T=60°C; 16 h; Inert atmosphere;
参考文献
Elmkaddem, Mohammed K.; Fischmeister, Cedric; Thomas, Christophe M.; Renaud, Jean-Luc
Chemical Communications, 2010 , vol. 46, # 6 p. 925 - 927
反应条件
ammonium cerium(IV) nitrate in water; acetonitrile T=0°C; 1.5 h;
参考文献
Abramovitch, Rudolph A.; You-Xiong, Wang
Heterocycles, 1987 , vol. 26, # 8 p. 2065 - 2068
反应条件
ammonium hydroxide T=135°C; 24 h;
参考文献
Haga, Takahiro; Fujikawa, Kan-ichi; Koyanagi, Tohru; Nakajima, Toshio; Hayashi, Kouji
Heterocycles, 1984 , vol. 22, # 1 p. 117 - 124
反应条件
ammonium hydroxide T=180°C; 8 h;
参考文献
Heterocycles, , vol. 22, # 1 p. 117 - 124
反应条件
1: 1.) Et3N, 2.) HCl / 1.) ethylene chloride, reflux, 24 h, 2.) water, reflux, 20 h 2: 54.2 percent / ceric ammonium nitrate / acetonitrile; H2O / 1.5 h / 0 °C View Scheme
参考文献
Heterocycles, , vol. 26, # 8 p. 2065 - 2068
反应条件
hydrogenchloride; water T=40°C; 6 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 16 p. 4573 - 4577
反应条件
1: 54.5 percent / antimony trifluoride / 0.17 h / Heating 2: 39 percent / aq. ammonia / 8 h / 180 °C View Scheme
参考文献
Heterocycles, , vol. 22, # 1 p. 117 - 124
反应条件
sulfuric acid; nitric acid T=0 - 20°C; Inert atmosphere;
参考文献
Sapegin, Alexander V.; Kalinin, Stanislav A.; Smirnov, Alexey V.; Dorogov, Mikhail V.; Krasavin, Mikhail
Tetrahedron, 2014 , vol. 70, # 5 p. 1077 - 1083
参考文献
State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University and The University of Oregon, Eugene Oregon; The Regents of the University of California; ACEA Pharmaceuticals, Inc.
Patent: US5620978 A1, 1997 ;
US 5620978 A
反应条件
1: nitric acid; sulfuric acid / 0 - 20 °C / |Inert atmosphere 2: sulfuric acid; sodium nitrite / water / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
Sapegin, Alexander V.; Kalinin, Stanislav A.; Smirnov, Alexey V.; Dorogov, Mikhail V.; Krasavin, Mikhail
Tetrahedron, 2014 , vol. 70, # 5 p. 1077 - 1083
