1-(4-氯苯基)-1-丙胺合成路线 （共 5 条）
反应条件
(i) HCO2NH4, (heating), (ii) aq. HCl; Multistep reaction;
参考文献
de Roocker,A.; de Radzitzky,P.
Bulletin des Societes Chimiques Belges, 1963 , vol. 72, p. 202 - 207
反应条件
thiophene; ammonia; hydrogen; RaNi in methanol
参考文献
Van Lommen, Guy; Doyon, Julien; Coesemans, Erwin; Boeckx, Staf; Cools, Marina; Buntinx, Mieke; Hermans, Bart; VanWauwe, Jean
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 3 p. 497 - 500
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran
1.2: hexane; tetrahydrofuran / ice-water bath
2.1: hexane; tetrahydrofuran; diethyl ether / 0.5 h / 20 °C
View Scheme
参考文献
Garcia-March; Garcia-Domenech; Galvez; Anton-Fos; De Julian-Ortiz; Giner-Pons; Recio-Iglesias
Journal of Pharmacy and Pharmacology, 1997 , vol. 49, # 1 p. 10 - 15
反应条件
in tetrahydrofuran; diethyl ether; hexane
T=20°C; Addition; 0.5 h;
参考文献
Garcia-March; Garcia-Domenech; Galvez; Anton-Fos; De Julian-Ortiz; Giner-Pons; Recio-Iglesias
Journal of Pharmacy and Pharmacology, 1997 , vol. 49, # 1 p. 10 - 15
参考文献
Goerlich et al.
Scientia Pharmaceutica, 1953 , vol. 21, p. 308,310
