反应条件
1: aq. NaIO4, SiO2 / CH2Cl2 / 0.25 h 2: NaBH4 / methanol / 1.5 h / -30 - -15 °C 3: 90 percent / imidazole / CH2Cl2 / 3 h 4: DIBAL-H / CH2Cl2; toluene / 2 h / -90 °C 5: molecular sieves (4 Angstroem), BF3*OEt2 / diethyl ether / 0.5 h 6: 1.) 1,1,1,3,3,3,-hexamethyldisilazane, ammonium sulfate, 2.) SnCl4, TMSOTf / 1.) reflux, 2 h, 2.) 1,2-dichloroethane, RT, 2 h 7: TBAF / tetrahydrofuran / 8 h 8: K2CO3 / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 2 p. 168 - 180
