(2S,4s)-4-氟吡咯烷-2-羧酰胺合成路线 （共 4 条）
反应条件
diethylamine in dichloromethane
T=20°C; 1.5 h;
参考文献
Singh, Rajendra P.; Umemoto, Teruo
Journal of Organic Chemistry, 2011 , vol. 76, # 9 p. 3113 - 3121
反应条件
1: With hydrogenchloride; water in butan-1-ol
T=50°C; 48 h;
2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
Novartis AG
Patent: US2009/163469 A1, 2009 ;
Location in patent: Page/Page column 40 ;
US 20090163469 A1
反应条件
1: pyridine; Fluolead; hydrogen fluoride / dichloromethane / 23 h / 0 - 20 °C / Inert atmosphere
2: ammonia / dichloromethane; water / 20 °C / Inert atmosphere
3: diethylamine / dichloromethane / 1.5 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Singh, Rajendra P.; Umemoto, Teruo
Journal of Organic Chemistry, 2011 , vol. 76, # 9 p. 3113 - 3121
反应条件
1: ammonia / dichloromethane; water / 20 °C / Inert atmosphere
2: diethylamine / dichloromethane / 1.5 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Singh, Rajendra P.; Umemoto, Teruo
Journal of Organic Chemistry, 2011 , vol. 76, # 9 p. 3113 - 3121
