N-(2,6-二甲基-4-氧代-1-环己-2,5-二烯亚基)乙酰胺合成路线 （共 6 条）
反应条件
water in acetone 6 h; Heating;
参考文献
Fernando; Calder; Ham
Journal of Medicinal Chemistry, 1980 , vol. 23, # 11 p. 1153 - 1158
反应条件
in water; acetonitrile T=25°C; hydrolysis in HCl solutions with various buffers, KCl or KCl-KClO3, pH range 0.3-10.5; KineticsMechanismProduct distribution;
参考文献
Novak, Michael; Bonham, Gayl A.; Mulero, Julio J.; Pelecanou, Maria; Zemis, Joseph N.; et al.
Journal of the American Chemical Society, 1989 , vol. 111, # 12 p. 4447 - 4456
反应条件
sodium dithionite; water in ethyl acetate T=50°C; 0.0833333 h;
参考文献
Fernando; Calder; Ham
Journal of Medicinal Chemistry, 1980 , vol. 23, # 11 p. 1153 - 1158
反应条件
lead(IV) acetate in ethyl acetate
T=45°C;
参考文献
Fernando; Calder; Ham
Journal of Medicinal Chemistry, 1980 , vol. 23, # 11 p. 1153 - 1158
反应条件
1: 89 percent / NaOAc / H2O / 1 h
2: 41 percent / Pb(OAc)4 / ethyl acetate / 45 °C
View Scheme
参考文献
Fernando; Calder; Ham
Journal of Medicinal Chemistry, 1980 , vol. 23, # 11 p. 1153 - 1158
反应条件
1: 1.) diazotized sulfanilic acid, 2.) sodium dithionite / 1.) 1 h, 2.) 65 deg C to 70 deg C
2: 89 percent / NaOAc / H2O / 1 h
3: 41 percent / Pb(OAc)4 / ethyl acetate / 45 °C
View Scheme
参考文献
Fernando; Calder; Ham
Journal of Medicinal Chemistry, 1980 , vol. 23, # 11 p. 1153 - 1158
