反应条件
1: 73 percent / N-bromosuccinimide / tetrahydrofuran / 0.33 h / 0 °C 2: 100 percent / K2CO3 / 0.5 h / 0 °C 3: 1) 0.5 N NaOH, 2) dl-10-camphorsulfonic acid / 1) THF, 0 deg C, 14 h, 2) CH2Cl2, RT, 20 h 4: 1) (COCl)2, DMSO, 2) NEt3 / 1a) CH2Cl2, -78 deg C, 15 min, 1b) -45 deg C, 1 h, 2a) -45 deg C, 20 min, 2b) 0 deg C, 15 min 5: 78 percent / p-TsOH*H2O / 14 h / Ambient temperature 6: 1) 60percent HOAc, 2) NaBH3CN, HOAc / 1) RT, 3 d, 2) EtOH, RT, 1 h View Scheme
参考文献
Tetrahedron, , vol. 49, # 28 p. 6195 - 6222
