N-Boc-反式-4-羟基-L-脯氨酸甲酯合成路线 （共 102 条）
反应条件
1: 93.8 percent / Ph3P, DEAD, CH3I / tetrahydrofuran / 10 h / Ambient temperature 2: 25 percent / DBU / toluene / 8 h / 80 - 90 °C View Scheme
参考文献
Dormoy, J.-R.
Synthesis, 1982 , # 9 p. 753 - 756
反应条件
1: in dichloromethane T=5°C; 12 h; 2: With sodium hydrogencarbonate in dichloromethane; water Product distribution / selectivity;
参考文献
WO2006/80401 A1, ;
Page/Page column 42-44 ;
反应条件
1: in toluene T=75°C; 4 h; 2: With potassium hydroxide in water; toluene Product distribution / selectivity;
参考文献
WO2006/80401 A1, ;
Page/Page column 36-38 ;
反应条件
triphenylphosphine in tetrahydrofuran T=0 - 20°C; 72 h;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2004/39367 A1, 2004 ;
Location in patent: Page/Page column 66-67 ;
WO 2004/039367 A1
反应条件
triethylamine in tetrahydrofuran 0.5 h; Cooling with ice;
参考文献
SPINIFEX PHARMACEUTICALS PTY LTD; MCCARTHY, Thomas David; NAYLOR, Alan
Patent: WO2013/102242 A1, 2013 ;
Location in patent: Page/Page column 97 ;
反应条件
triethylamine in dichloromethane
参考文献
Banyu Pharmaceutical Co., Ltd.
Patent: US5550121 A1, 1996 ;
反应条件
di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine in tetrahydrofuran T=70°C; Mitsunobu Displacement; 15 h;
参考文献
Kim, Mira; Jeon, Jiyoung; Song, Jiyeon; Suh, Kwee Hyun; Kim, Young Hoon; Min, Kyung Hoon; Lee, Kwang-Ok
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3140 - 3144
反应条件
1: With sodium hydroxide in ethanol; water 4 h; 2: With citric acid in ethanol; water
参考文献
Chapal, Nicolas; McNicol, Patricia; Jette, Lucie
Patent: US2006/223884 A1, 2006 ;
Location in patent: Page/Page column 60 ;
反应条件
lithium borohydride in tetrahydrofuran T=0 - 20°C;
参考文献
Peterson, Mark L.; Vince, Robert
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2787 - 2797
反应条件
1-propanephosphonic acid cyclic anhydride in ethyl acetate T=0°C; 3 h;
参考文献
CLARIANT GMBH
Patent: WO2005/123632 A1, 2005 ;
Location in patent: Page/Page column 6-7 ;
