N-Boc-反式-4-羟基-L-脯氨酸甲酯合成路线 （共 102 条）
反应条件
4,4'-diaminostilbene-2,2'-disulfonic acid T=0 - 20°C;
参考文献
Journal of Organic Chemistry, , vol. 73, # 20 p. 8106 - 8108
反应条件
1: in dichloromethane T=5°C; 12 h; 2: With sodium hydrogencarbonate in dichloromethane; water Product distribution / selectivity;
参考文献
WO2006/80401 A1, ;
Page/Page column 42-44 ;
反应条件
1: in toluene T=75°C; 4 h; 2: With potassium hydroxide in water; toluene Product distribution / selectivity;
参考文献
WO2006/80401 A1, ;
Page/Page column 36-38 ;
反应条件
1.1: triethylamine / dichloromethane / 1.83 h / 0 - 20 °C 2.1: dimethyl sulfoxide / 72 h / 55 °C / |Inert atmosphere 3.1: sodium hydroxide; water / methanol / 20 °C 3.2: pH 2 View Scheme
参考文献
LONG, Daniel D.; MCKINNELL, Robert Murray; JIANG, Lan; LOO, Mandy; LEPACK, Kassandra; VAN ORDEN, Lori Jean; OGAWA, Gavin; HUANG, Xiaojun; ZHANG, Weijiang
Patent: US2013/115194 A1, 2013 ;
反应条件
1: 96 percent / DPPA; DEAD; PPh3 / tetrahydrofuran 2: LiOH / tetrahydrofuran; H2O View Scheme
参考文献
Nagel, Yvonne A.; Kuemin, Michael; Wennemers, Helma
Chimia, 2011 , vol. 65, # 4 p. 264 - 267
反应条件
1: 56.2 g / triethylamine / CH2Cl2 / 3 h / 0 - 5 °C 2: 88.7 percent / dimethylsulfoxide / 90 °C 3: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 5 p. 1399 - 1415
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine in dichloromethane T=-78 - 0°C; Oxidation;
参考文献
O'Connell, Celeste E.; Rowell, Cheryl A.; Ackermann, Karen; Garcia, Ana Maria; Lewis, Michael D.; Kowalczyk, James J.
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 5 p. 740 - 742
反应条件
1: 56.2 g / triethylamine / CH2Cl2 / 3 h / 0 - 5 °C 2: 88.7 percent / dimethylsulfoxide / 90 °C 3: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C View Scheme
参考文献
Zhang, Xiaojun; Schmitt, Aaron C.; Jiang, Wen
Tetrahedron Letters, 2001 , vol. 42, # 32 p. 5335 - 5338
反应条件
1: 1H-imidazole / N,N-dimethyl-formamide / 1.5 h / 20 °C / |Inert atmosphere 2: lithium borohydride / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere 3: triethylamine / dichloromethane / 0 °C / |Inert atmosphere 4: lithium triethylborohydride / tetrahydrofuran / 2 h / 20 °C / |Cooling with ice; |Inert atmosphere 5: tetrabutyl ammonium fluoride / tetrahydrofuran / |Inert atmosphere View Scheme
参考文献
Fransson, Rebecca; McCracken, Alison N.; Chen, Bin; McMonigle, Ryan J.; Edinger, Aimee L.; Hanessian, Stephen
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 10 p. 969 - 973
反应条件
1: 56.2 g / triethylamine / CH2Cl2 / 3 h / 0 - 5 °C 2: 88.7 percent / dimethylsulfoxide / 90 °C 3: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C View Scheme
参考文献
Zhang, Xiaojun; Schmitt, Aaron C.; Jiang, Wen
Tetrahedron Letters, 2001 , vol. 42, # 32 p. 5335 - 5338
