N-Boc-反式-4-羟基-L-脯氨酸甲酯合成路线 （共 102 条）
反应条件
1: Et3N 2: NaN3 3: H2 / Pd/BaSO4 View Scheme
参考文献
Torino, Domenica; Mollica, Adriano; Pinnen, Francesco; Feliciani, Federica; Spisani, Susanna; Lucente, Gino
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 251 - 259
反应条件
1.1: sodium periodate; ruthenium trichloride 3.1: diethylzinc; trifluoroacetic acid / hexane; dichloromethane / 1 h / -5 °C / Inert atmosphere 3.2: 72 h / -5 - 30 °C / Inert atmosphere 3.3: 24 h / 20 °C 4.1: water; sodium hydroxide / ethanol / 24 h View Scheme
参考文献
Tetrahedron Letters, , vol. 53, # 30 p. 3847 - 3849
反应条件
1: 56.2 g / triethylamine / CH2Cl2 / 3 h / 0 - 5 °C 2: 88.7 percent / dimethylsulfoxide / 90 °C 3: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C 4: 100 percent / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 5: 90.8 percent / sodium azide / dimethylsulfoxide / 90 °C 6: H2 / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr View Scheme
参考文献
Torino, Domenica; Mollica, Adriano; Pinnen, Francesco; Feliciani, Federica; Spisani, Susanna; Lucente, Gino
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 251 - 259
反应条件
1.1: lithium borohydride / tetrahydrofuran / 26 h / 0 - 20 °C 2.1: pyridine / dichloromethane / 18 h / 40 °C 3.1: trimethylsilylazide; tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 70 °C 4.1: triethylamine / dichloromethane / 0.5 h / 0 °C 5.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C 5.2: 18 h View Scheme
参考文献
Beinat, Corinne; Banister, Samuel D.; McErlean, Christopher S.P.; Kassiou, Michael
Tetrahedron Letters, 2013 , vol. 54, # 39 p. 5345 - 5347
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=20°C; Mitsunobu reaction; 12 h;
参考文献
Daiichi Pharmaceutical Co., LTD.
Patent: US2003/78249 A1, 2003 ;
反应条件
sodium hydroxide in tetrahydrofuran T=0°C; 19 h;
参考文献
GILEAD SCIENCES, INC.; DESAI, Manoj, C.; HUI, Hon Chung; LIU, Hongtao; SUN, Jianyu; XU, Lianhong
Patent: WO2012/88156 A1, 2012 ;
Location in patent: Page/Page column 58-59 ;
WO 2012/088156 A1
反应条件
silver(l) oxide in dichloromethane 24 h; Inert atmosphere; Reflux;
参考文献
Singh, Ritesh; Panda, Gautam
RSC Advances, 2013 , vol. 3, # 42 p. 19533 - 19544
反应条件
triphenylphosphine; diethylazodicarboxylate
参考文献
Jordan, Stephan; Schwemler, Christoph; Kosch, Winfried; Kretschmer, Axel; Schwenner, Eckhardt; Stropp, Udo; Mielke, Burkhard
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 6 p. 681 - 686
反应条件
1: 100 percent / imidazole / dimethylformamide / 20 °C 2: 96 percent / aq. LiOH / methanol / 1 h / 45 °C View Scheme
参考文献
Watts, John; Luu, Lien; McKee, Vickie; Carey, Ed; Kelleher, Fintan
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 6 p. 1035 - 1042
反应条件
hydrogenchloride in 1,4-dioxane; dichloromethane T=20°C; 4 h;
参考文献
TaiGen Biotechnology Co., Ltd.
Patent: US2008/108632 A1, 2008 ;
Location in patent: Page/Page column 20 ;
US 20080108632 A1
