N-Boc-反式-4-羟基-L-脯氨酸甲酯合成路线

SUNSHINE LAKE PHARMA CO.,LTD.; ZHANG, Jiancun; ZHANG, Yingjun; XIE, Hongming; REN, Qingyun; HU, Bailin; FU, Changping; WU, Xiwei; LI, Shifeng; WANG, Chenglin; ZHANG, Zhikeng
Patent: WO2014/82379 A1, 2014 ;

74844-91-0N-Boc-反式-4-羟基-L-脯氨酸甲酯

203866-15-3N-Boc-4,4-二氟-L-脯氨酸

参考文献

SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; LI, Shifeng; FU, Changping; HU, Bailin; WU, Xiwei; TANG, Changhua
Patent: WO2014/82380 A1, 2014 ;

74844-91-0N-Boc-反式-4-羟基-L-脯氨酸甲酯

203866-14-2N-Boc-反式-4-氟-L-脯氨酸

参考文献

Chiba, Jun; Takayama, Gensuke; Takashi, Tohru; Yokoyama, Mika; Nakayama, Atsushi; Baldwin, John J.; McDonald, Edward; Moriarty, Kevin J.; Sarko, Christopher R.; Saionz, Kurt W.; Swanson, Robert; Hussain, Zahid; Wong, Angela; MacHinaga, Nobuo
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 8 p. 2725 - 2746

74844-91-0N-Boc-反式-4-羟基-L-脯氨酸甲酯

121147-97-5(2S,4R)-4-叠氮基-1,2-吡咯烷二甲酸1-(1,1-二甲基乙基)2-甲酯

参考文献

Kuemin, Michael; Sonntag, Louis-Sebastian; Wennemers, Helma
Journal of the American Chemical Society, 2007 , vol. 129, # 3 p. 466 - 467

74844-91-0N-Boc-反式-4-羟基-L-脯氨酸甲酯

114676-67-4(2S,4r)-1-boc-4-(叔丁基二甲基甲硅烷基氧基)-2-(羟基甲基)吡咯烷

参考文献

ROTTAPHARM S.P.A.; STASI, Luigi, Piero; ROVATI, Lucio
Patent: WO2011/6960 A1, 2011 ;
WO 2011/006960 A1