4-(N,N-dimethlyamino)pyridine; phosphate buffer in toluene T=90°C; 192 h;

potassium hydride; sodium hydride in tetrahydrofuran 0.666667 h; Heating;

potassium hydroxide in diethyl ether T=0°C;

1: 1.) diisopropylamine, 1,10-phenanthroline, n-BuLi / 1.) ether, 1 deg C, 1 h, 2.) 1 deg C, 35 min, 1 deg C to room temp. 30 min 2: 40percent aq. KOH / diethyl ether / 0 °C View Scheme