1-(4-甲氧基苯基)-4-(4-硝基苯基)哌嗪合成路线 （共 11 条）
反应条件
potassium carbonate in dimethyl sulfoxide T=160°C;
参考文献
THE JOHNS HOPKINS UNIVERSITY
Patent: WO2008/124132 A1, 2008 ;
Location in patent: Page/Page column 46 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide; isobutyl methylketone
参考文献
Janssen Pharmaceutica, N.V.
Patent: US4267179 A1, 1981 ;
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate in dimethyl sulfoxide Arylation; Heating;
参考文献
Hepperle, Michael; Eckert, Jeffrey; Gala, Dinesh; Shen, Lan; Anderson Evans; Goodman, Andrew
Tetrahedron Letters, 2002 , vol. 43, # 18 p. 3359 - 3363
反应条件
1: 82 percent / (+)-BINAP; NaOt-Bu / Pd2(dba)3 / toluene; tetrahydrofuran / 24 h / 80 - 90 °C 2: 77 percent / K2CO3; TBAI / dimethylsulfoxide / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 18 p. 3359 - 3363
反应条件
1: 74 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating 2: 61 percent / pyridine / CHCl3 / 3 h 3: 63 percent / hydrazine hydrate / dioxane / 3 h / Heating 4: 28 percent / NaOAc / butan-1-ol 5: 57 percent / KOH / dimethylsulfoxide / 14 h 6: 38 percent / 48percent aq. HBr / Heating View Scheme
参考文献
Heeres; Backx; Van Cutsem
Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 894 - 900
反应条件
1: 74 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating 2: 61 percent / pyridine / CHCl3 / 3 h 3: 63 percent / hydrazine hydrate / dioxane / 3 h / Heating 4: 28 percent / NaOAc / butan-1-ol View Scheme
参考文献
Heeres; Backx; Van Cutsem
Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 894 - 900
反应条件
1: H2 / Pd/C 2: HBr / Heating View Scheme
参考文献
Hepperle, Michael; Eckert, Jeffrey; Gala, Dinesh
Tetrahedron Letters, 1999 , vol. 40, # 31 p. 5655 - 5659
反应条件
palladium 10 on activated carbon; hydrazine hydrate in ethanol Reflux;
参考文献
Shi, Wei; Nacev, Benjamin A.; Bhat, Shridhar; Liu, Jun O.
ACS Medicinal Chemistry Letters, 2010 , vol. 1, # 4 p. 155 - 159
反应条件
1: 74 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating 2: 61 percent / pyridine / CHCl3 / 3 h 3: 63 percent / hydrazine hydrate / dioxane / 3 h / Heating View Scheme
参考文献
Heeres; Backx; Van Cutsem
Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 894 - 900
反应条件
1: 74 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating 2: 61 percent / pyridine / CHCl3 / 3 h View Scheme
参考文献
Heeres; Backx; Van Cutsem
Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 894 - 900
