N-{4-[4-(4-甲氧基苯基)-1-哌嗪基]苯基}氨基甲酰肼合成路线 （共 9 条）
反应条件
hydrazine hydrate in 1,4-dioxane 3 h; Heating;
参考文献
Heeres; Backx; Van Cutsem
Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 894 - 900
反应条件
1: 67 percent / K2CO3 / dimethylsulfoxide / 120 °C 2: 74 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating 3: 61 percent / pyridine / CHCl3 / 3 h 4: 63 percent / hydrazine hydrate / dioxane / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 7 p. 894 - 900
反应条件
1: 67 percent / K2CO3 / dimethylsulfoxide / 120 °C 2: 74 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating 3: 61 percent / pyridine / CHCl3 / 3 h 4: 63 percent / hydrazine hydrate / dioxane / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 7 p. 894 - 900
反应条件
1: 74 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating 2: 61 percent / pyridine / CHCl3 / 3 h 3: 63 percent / hydrazine hydrate / dioxane / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 7 p. 894 - 900
反应条件
1: 61 percent / pyridine / CHCl3 / 3 h 2: 63 percent / hydrazine hydrate / dioxane / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 7 p. 894 - 900
反应条件
1: 28 percent / NaOAc / butan-1-ol 2: 57 percent / KOH / dimethylsulfoxide / 14 h 3: 38 percent / 48percent aq. HBr / Heating View Scheme
参考文献
Heeres; Backx; Van Cutsem
Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 894 - 900
反应条件
in dimethyl sulfoxide T=160°C; 2 h;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2006/67139 A1, 2006 ;
Location in patent: Page/Page column 34 ;
WO 2006/067139 A1
反应条件
sodium acetate in butan-1-ol
参考文献
Heeres; Backx; Van Cutsem
Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 894 - 900
反应条件
acetic acid in N,N-dimethyl-formamide T=80°C;
参考文献
ACS Medicinal Chemistry Letters, , vol. 1, # 4 p. 155 - 159
