N,1-二三苯甲基组氨酸合成路线 （共 12 条）
反应条件
1: conc. HCl / acetone / 5 °C 2: 2 M ammonia / 0.05 h 3: 88 percent / 1 M K2CO3 / propan-2-ol / 0.67 h / 30 - 35 °C View Scheme
参考文献
Pozdnev, V. F.
Chemistry of Natural Compounds, 1982 , vol. 18, # 3 p. 322 - 327
Khimiya Prirodnykh Soedinenii, 1982 , # 3 p. 349 - 354
反应条件
1: conc. HCl / acetone / 5 °C 2: 2 M ammonia / 0.05 h View Scheme
参考文献
Chemistry of Natural Compounds, , vol. 18, # 3 p. 322 - 327
Khimiya Prirodnykh Soedinenii, , # 3 p. 349 - 354
反应条件
dichloromethane und anschliessendes Erwaermen mit wss.-methanol.KOH und mit wss.Essigsaeure;
参考文献
Amiard et al.
Bulletin de la Societe Chimique de France, 1955 , p. 1464
反应条件
1: With zinc(II) chloride in acetonitrile
T=30 - 40°C; 0.166667 - 0.5 h;
2: With triethylamine in acetonitrile
Product distribution / selectivity;
参考文献
Universita degli Studi di Roma "La Sapienza"
Patent: WO2007/9944 A1, 2007 ;
Location in patent: Page/Page column 27-28 ;
反应条件
sodium hydroxide; diethylamine; isopropyl alcohol
参考文献
Stelakatos et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 2884,2887
反应条件
1: 1.) triethylamine / 1.) dimethylformamide, chloroform, 30-35 deg C, 20 min; 2.) 1 h
2: methanol
View Scheme
参考文献
Pozdnev, V. F.
Chemistry of Natural Compounds, 1982 , vol. 18, # 3 p. 322 - 327
Khimiya Prirodnykh Soedinenii, 1982 , # 3 p. 349 - 354
反应条件
1: 1.) triethylamine / 1.) dimethylformamide, chloroform, 30-35 deg C, 20 min; 2.) 1 h
2: methanol
View Scheme
参考文献
Pozdnev, V. F.
Chemistry of Natural Compounds, 1982 , vol. 18, # 3 p. 322 - 327
Khimiya Prirodnykh Soedinenii, 1982 , # 3 p. 349 - 354
反应条件
1: 1.) triethylamine / 1.) dimethylformamide, chloroform
2: methanol
View Scheme
参考文献
Pozdnev, V. F.
Chemistry of Natural Compounds, 1982 , vol. 18, # 3 p. 322 - 327
Khimiya Prirodnykh Soedinenii, 1982 , # 3 p. 349 - 354
反应条件
1: HCl (g)
2: 1.) triethylamine, 2.) KOH / 1.) CHCl3, 0 deg C, 16 h, 2.) propylene glycol, reflux, 15 min
View Scheme
参考文献
Visser, H. G. J.; Nolte, R. J. M.; Zwikker, J. W.; Drenth, W.
Journal of Organic Chemistry, 1985 , vol. 50, # 17 p. 3133 - 3137
反应条件
potassium hydroxide; triethylamine
1.) CHCl3, 0 deg C, 16 h, 2.) propylene glycol, reflux, 15 min; Yield given. Multistep reaction;
参考文献
Visser, H. G. J.; Nolte, R. J. M.; Zwikker, J. W.; Drenth, W.
Journal of Organic Chemistry, 1985 , vol. 50, # 17 p. 3133 - 3137
