(+/-)-2,2-二溴-1,1-二联萘合成路线 （共 37 条）
反应条件
copper(l) iodide; sodium azide; N-methyl-2-(methylamino)ethylamine in dimethyl sulfoxide T=100°C; 48 h; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 75, # 14 p. 4887 - 4890
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethanol; toluene T=100°C; 24 h;
参考文献
European Journal of Organic Chemistry, , # 4 p. 701 - 709
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethanol; toluene T=100°C; 24 h;
参考文献
European Journal of Organic Chemistry, , # 4 p. 701 - 709
反应条件
tert.-butyl lithium; sulfur
1) THF, dry ice/acetone bath, 4h, 2) 25 deg C, 0.5h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Murata, Shizuaki; Suzuki, Toshiyasu; Yanagisawa, Akira; Suga, Seiji
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 2 p. 433 - 438
反应条件
1: 1) t-BuLi / 1) THF, -90 deg C
2: 21 percent / TiCl3, Zn/Cu / Heating
View Scheme
参考文献
Dubois, Fabien; Gingras, Marc
Tetrahedron Letters, 1998 , vol. 39, # 28 p. 5039 - 5040
反应条件
1: With tert.-butyl lithium in tetrahydrofuran; pentane
T=-78°C; 0.25 h;
2: With boric acid trimethyl ester in tetrahydrofuran; pentane
T=-78 - 0°C; 1 h;
3: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran; pentane
T=0 - 20°C; Further stages.;
参考文献
Clayden, Jonathan; Kubinski, Przemyslaw M.; Sammiceli, Federica; Helliwell, Madeleine; Diorazio, Louis
Tetrahedron, 2004 , vol. 60, # 20 p. 4387 - 4397
反应条件
1.1: t-BuLi / pentane; tetrahydrofuran / 0.25 h / -78 °C
1.2: trimethyl borate / tetrahydrofuran; pentane / 1 h / -78 - 0 °C
1.3: 55 percent / aq. H2O2; NaOH / tetrahydrofuran; pentane / 0 - 20 °C
2.1: 65 percent / potassium carbonate / acetone / 24 h / Heating
3.1: t-BuLi / tetrahydrofuran; pentane / -78 °C
View Scheme
参考文献
Clayden, Jonathan; Kubinski, Przemyslaw M.; Sammiceli, Federica; Helliwell, Madeleine; Diorazio, Louis
Tetrahedron, 2004 , vol. 60, # 20 p. 4387 - 4397
