(S)-(+)-2-甲基哌嗪合成路线 （共 22 条）
反应条件
10 Pd/C; hydrogen; acetic acid in methanol T=20°C; P=3800.26 Torr; 24 h;
参考文献
Maity, Prantik; Koenig, Burkhard
Organic Letters, 2008 , vol. 10, # 7 p. 1473 - 1476
反应条件
acetic acid in water T=15 - 75°C; 7 h; Product distribution / selectivity;
参考文献
Toray Fine Chemicals Co., Ltd.
Patent: EP1548010 A1, 2005 ;
Location in patent: Page/Page column 22-23 ;
反应条件
1: 83 percent / H2 / 10percent Pd/C / methanol / 18 h / 3040 Torr 2: BH3*THF / tetrahydrofuran / 16 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 1 p. 168 - 174
反应条件
1: triethylamine / methanol / 20 h / Heating 2: 79 percent / lithium aluminum hydride / tetrahydrofuran / 36 h / 0 - 20 °C 3: 74 percent / hydrogen; acetic acid / palladium on carbon / methanol / 24 h / 20 °C / 760 Torr View Scheme
参考文献
Synthetic Communications, , vol. 34, # 22 p. 4111 - 4118
反应条件
1: 79 percent / lithium aluminum hydride / tetrahydrofuran / 36 h / 0 - 20 °C 2: 74 percent / hydrogen; acetic acid / palladium on carbon / methanol / 24 h / 20 °C / 760 Torr View Scheme
参考文献
Synthetic Communications, , vol. 34, # 22 p. 4111 - 4118
反应条件
borane-THF in tetrahydrofuran 16 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 1 p. 168 - 174
反应条件
palladium on magnesium oxide in acetonitrile T=160°C; 20 h; AutoclaveInert atmosphere;
参考文献
Chemistry - A European Journal, , vol. 16, # 1 p. 254 - 260
参考文献
Toda, Fumio; Tanaka, Koichi; Kido, Masaru
Chemistry Letters, 1988 , p. 513 - 516
反应条件
1: in butan-1-ol T=0 - 8°C; 2 h; 2: With hydrogenchloride in water; toluene T=0°C; pH=1.0; 0.5 h; 3: With sodium hydroxide in water; toluene T=60 - 170°C; pH=11.8; 0.5 h; Product distribution / selectivity;
参考文献
Toray Fine Chemicals Co., Ltd.
Patent: EP1548010 A1, 2005 ;
Location in patent: Page/Page column 21-22 ;
反应条件
1: in butan-1-ol T=0 - 8°C; 2 h; 2: With hydrogenchloride in water; toluene T=0°C; pH=1.0; 0.5 h; 3: With sodium hydroxide in water; toluene T=60 - 170°C; pH=11.8; 0.5 h; Product distribution / selectivity;
参考文献
Toray Fine Chemicals Co., Ltd.
Patent: EP1548010 A1, 2005 ;
Location in patent: Page/Page column 21-22 ;
