(S)-(+)-2-甲基哌嗪合成路线 （共 22 条）
参考文献
Cowart, Marlon D.; Bhatia, Pramila A.; Daanen, Jerome F.; Stewart, Andrew O.; Patel, Meena V.; Kolasa, Teodozyj; Brioni, Jorge D.; Rohde, Jeffrey
Patent: US2002/169166 A1, 2002 ;
反应条件
1: in butan-1-ol
T=0 - 8°C; 2 h;
2: With hydrogenchloride in water; toluene
T=0°C; pH=1.0; 0.5 h;
3: With sodium hydroxide in water; toluene
T=60 - 170°C; pH=11.8; 0.5 h; Product distribution / selectivity;
参考文献
Toray Fine Chemicals Co., Ltd.
Patent: EP1548010 A1, 2005 ;
Location in patent: Page/Page column 21 ;
